Christian Y Mardin1, Sami Hosari2. 1. Universitätsaugenklinik Erlangen, FAU Erlangen-Nürnberg, 91054, Erlangen, Deutschland. Christian.Mardin@uk-erlangen.de. 2. Universitätsaugenklinik Erlangen, FAU Erlangen-Nürnberg, 91054, Erlangen, Deutschland.
Abstract
BACKGROUND: Optical coherence tomography angiography (OCTA) enables a noninvasive detailed imaging of retinal and choroidal vessels of the fundus. In neuronal diseases changes in retinal structures can be imaged and measured with OCT and OCTA. OBJECTIVE: Can OCTA be used in neuronal diseases? MATERIAL AND METHODS: Evaluation of recent scientific articles and studies extracted from Medline on the topic of OCTA and neuronal diseases. RESULTS: It could be shown that Alzheimer type dementia, Parkinson's disease, multiple sclerosis. cerebral infarction and CADASIL are neuronal diseases with rarification of retinal vessels and atrophy of the retinal layers in the ocular fundus. CONCLUSION: These findings are beyond all changes which can be appreciated with ophthalmoscopy and OCTA parameters could serve in the future as supplementary biomarkers for assessment of the retinal-neurovascular coupling in these diseases.
BACKGROUND: Optical coherence tomography angiography (OCTA) enables a noninvasive detailed imaging of retinal and choroidal vessels of the fundus. In neuronal diseases changes in retinal structures can be imaged and measured with OCT and OCTA. OBJECTIVE: Can OCTA be used in neuronal diseases? MATERIAL AND METHODS: Evaluation of recent scientific articles and studies extracted from Medline on the topic of OCTA and neuronal diseases. RESULTS: It could be shown that Alzheimer type dementia, Parkinson's disease, multiple sclerosis. cerebral infarction and CADASIL are neuronal diseases with rarification of retinal vessels and atrophy of the retinal layers in the ocular fundus. CONCLUSION: These findings are beyond all changes which can be appreciated with ophthalmoscopy and OCTA parameters could serve in the future as supplementary biomarkers for assessment of the retinal-neurovascular coupling in these diseases.
Authors: Manju L Subramanian; Viha Vig; Jaeyoon Chung; Marissa G Fiorello; Weiming Xia; Henrik Zetterberg; Kaj Blennow; Madeleine Zetterberg; Farah Shareef; Nicole H Siegel; Steven Ness; Gyungah R Jun; Thor D Stein Journal: Alzheimers Res Ther Date: 2020-09-17 Impact factor: 6.982