Marianna Cortese1, Tanuja Chitnis2, Alberto Ascherio2, Kassandra L Munger2. 1. From the Departments of Nutrition (M.C., A.A., K.L.M.) and Epidemiology (A.A.), Harvard T.H. Chan School of Public Health, Boston, MA; Department of Global Public Health and Primary Care (M.C.), University of Bergen, Norway; and Partners Multiple Sclerosis Center (T.C.) and Channing Division of Network Medicine, Department of Medicine (A.A.), Brigham and Women's Hospital, Boston, MA. mcortese@hsph.harvard.edu. 2. From the Departments of Nutrition (M.C., A.A., K.L.M.) and Epidemiology (A.A.), Harvard T.H. Chan School of Public Health, Boston, MA; Department of Global Public Health and Primary Care (M.C.), University of Bergen, Norway; and Partners Multiple Sclerosis Center (T.C.) and Channing Division of Network Medicine, Department of Medicine (A.A.), Brigham and Women's Hospital, Boston, MA.
Abstract
OBJECTIVE: To investigate the association between mineral intake (potassium, magnesium, calcium, phosphorus, iron, zinc, manganese, copper) and multiple sclerosis (MS) risk. METHODS: In a prospective cohort study, we assessed dietary and supplemental mineral intake by a validated food frequency questionnaire administered every 4 years to 80,920 nurses in the Nurses' Health Study (1984-2002) and 94,511 in the Nurses' Health Study II (1991-2007). There were 479 new MS cases during follow-up. We estimated hazard ratios and 95% confidence intervals for the association of energy-adjusted mineral intake with MS risk using Cox regression, adjusting for age, residence latitude at age 15, ancestry, body mass index at age 18, supplemental vitamin D, smoking, and total energy intake. RESULTS: We did not find any association between the minerals and MS risk, either for baseline or cumulative intake during follow-up. The associations were null comparing women with highest to those with lowest intakes in quintiles or deciles and there was no significant trend for higher intakes (p trend across baseline quintiles: potassium 0.35, magnesium 0.13, calcium 0.22, phosphorus 0.97, iron 0.85, zinc 0.67, manganese 0.48, copper 0.59). CONCLUSIONS: Our findings suggest that mineral intake is not an important determinant of MS risk.
OBJECTIVE: To investigate the association between mineral intake (potassium, magnesium, calcium, phosphorus, iron, zinc, manganese, copper) and multiple sclerosis (MS) risk. METHODS: In a prospective cohort study, we assessed dietary and supplemental mineral intake by a validated food frequency questionnaire administered every 4 years to 80,920 nurses in the Nurses' Health Study (1984-2002) and 94,511 in the Nurses' Health Study II (1991-2007). There were 479 new MS cases during follow-up. We estimated hazard ratios and 95% confidence intervals for the association of energy-adjusted mineral intake with MS risk using Cox regression, adjusting for age, residence latitude at age 15, ancestry, body mass index at age 18, supplemental vitamin D, smoking, and total energy intake. RESULTS: We did not find any association between the minerals and MS risk, either for baseline or cumulative intake during follow-up. The associations were null comparing women with highest to those with lowest intakes in quintiles or deciles and there was no significant trend for higher intakes (p trend across baseline quintiles: potassium 0.35, magnesium 0.13, calcium 0.22, phosphorus 0.97, iron 0.85, zinc 0.67, manganese 0.48, copper 0.59). CONCLUSIONS: Our findings suggest that mineral intake is not an important determinant of MS risk.
Authors: Changzheng Yuan; Donna Spiegelman; Eric B Rimm; Bernard A Rosner; Meir J Stampfer; Junaidah B Barnett; Jorge E Chavarro; Amy F Subar; Laura K Sampson; Walter C Willett Journal: Am J Epidemiol Date: 2017-04-01 Impact factor: 4.897
Authors: Julia Pakpoor; Brandon Seminatore; Jennifer S Graves; Teri Schreiner; Amy T Waldman; Timothy E Lotze; Anita Belman; Benjamin M Greenberg; Bianca Weinstock-Guttman; Gregory Aaen; Jan-Mendelt Tillema; Jamie C McDonald; Janace Hart; Jayne M Ness; Yolanda Harris; Jennifer Rubin; Meghan Candee; Lauren Krupp; Mark Gorman; Leslie Benson; Moses Rodriguez; Tanuja Chitnis; Soe Mar; Ilana Kahn; John Rose; Suzan L Carmichael; Shelly Roalstad; Michael Waltz; T Charles Casper; Emmanuelle Waubant Journal: Mult Scler Date: 2017-06-13 Impact factor: 6.312