Vincenzo Di Nunno1, Veronica Mollica1, Lidia Gatto1, Matteo Santoni2, Laura Cosmai3, Camillo Porta4, Francesco Massari1. 1. Division of Oncology, S.Orsola-Malpighi Hospital, Bologna, Italy. 2. Oncology Unit, Macerata Hospital, Macerata, Italy. 3. Onco-Nephrology Outpatient Clinic, Division of Nephrology & Dialysis, San Carlo Borromeo Hospital, ASST Santi Paolo e Carlo, Milan, Italy. 4. Department of Internal Medicine, University of Pavia & Division of Traslational Oncology, IRCCS Istituti Clinici Scientifici Maugeri, Pavia, Italy.
Abstract
AIM: Estimate prognosis and clinical outcome of patients with localized or metastatic renal cell carcinoma (RCC) is an important issue which drive our medical decisions. METHODS: We carried out a meta-analysis of available clinical studies exploring neutrophil-to-lymphocyte ratio (NLR) in RCC in order to evaluate if this ratio could be correlated to overall survival (OS) and progression-free survival (PFS) of patients with localized/metastatic RCC. RESULTS: In overall population higher NLR resulted in worst OS and PFS (OS pooled hazard ratio of 1.80; 95% CI: 1.61-2.00; I2 45%; PFS pooled hazard ratio of 1.69; 95% CI: 1.42-2.01; I2 81%), this negative correlation was also confirmed in both metastatic and nonmetastatic patients. CONCLUSION: The NLR ratio is a variable correlated to prognosis in RCC patients.
AIM: Estimate prognosis and clinical outcome of patients with localized or metastatic renal cell carcinoma (RCC) is an important issue which drive our medical decisions. METHODS: We carried out a meta-analysis of available clinical studies exploring neutrophil-to-lymphocyte ratio (NLR) in RCC in order to evaluate if this ratio could be correlated to overall survival (OS) and progression-free survival (PFS) of patients with localized/metastatic RCC. RESULTS: In overall population higher NLR resulted in worst OS and PFS (OS pooled hazard ratio of 1.80; 95% CI: 1.61-2.00; I2 45%; PFS pooled hazard ratio of 1.69; 95% CI: 1.42-2.01; I2 81%), this negative correlation was also confirmed in both metastatic and nonmetastatic patients. CONCLUSION: The NLR ratio is a variable correlated to prognosis in RCCpatients.
Authors: Mehmet A Bilen; Brian I Rini; Martin H Voss; James Larkin; John B A G Haanen; Laurence Albiges; Lance C Pagliaro; Eric G Voog; Elaine T Lam; Nikolay Kislov; Bradley A McGregor; Aly-Khan A Lalani; Bo Huang; Alessandra di Pietro; Stan Krulewicz; Paul B Robbins; Toni K Choueiri Journal: Clin Cancer Res Date: 2022-02-15 Impact factor: 13.801
Authors: D Viñal; L Gutierrez-Sainz; D Martinez; J A Garcia-Cuesta; J Pedregosa; J Villamayor; L Ostios; D Sanchez-Cabrero; O Higuera; A Pinto; N Rodriguez-Salas; E Espinosa; J de Castro; J Feliu Journal: Clin Transl Oncol Date: 2020-11-23 Impact factor: 3.405
Authors: Anup Patel; Alain Ravaud; Robert J Motzer; Allan J Pantuck; Michael Staehler; Bernard Escudier; Jean-François Martini; Mariajose Lechuga; Xun Lin; Daniel J George Journal: Clin Cancer Res Date: 2020-06-16 Impact factor: 12.531