Tatsunori Toida1,2, Yuji Sato3, Hiroyuki Komatsu4, Kazuo Kitamura4,5, Shouichi Fujimoto6,3. 1. Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan, t.toida@med.miyazaki-u.ac.jp. 2. Department of Internal Medicine, Miyazaki Prefectural Nobeoka Hospital, Nobeoka, Japan, t.toida@med.miyazaki-u.ac.jp. 3. Dialysis Division, University of Miyazaki Hospital, Miyazaki, Japan. 4. Department of Nephrology, University of Miyazaki Hospital, Miyazaki, Japan. 5. Division of Circulatory and Body Fluid Regulaton, Department of Internal Medicine, University of Miyazaki, Miyazaki, Japan. 6. Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Abstract
BACKGROUND/AIMS: Uric acid (UA) levels are affected by changes in dialysis; however, the relationship between the pre- and postdialysis UA difference (UAD) and mortality remains unclear. METHODS: A total of 1,073 patients receiving maintenance hemodialysis (HD) were enrolled in this cohort study and followed up for 5 years. Patients were divided into quartile categories according to baseline UAD. Cox's regression analyses were used to investigate the relationship between UAD categories and all-cause and cardiovascular (CV) mortalities while adjusting for potential confounders. RESULTS: A total of 280 patients died of all causes, including 121 CV deaths, during the follow-up. In the analysis for all-cause mortality, hazard ratios were significantly higher in the lowest UAD group (< 4.7 mg/dL) than in the highest UAD group (> 6.2 mg/dL). A correlation was not observed with CV mortality. CONCLUSION: UAD correlated with all-cause mortality. UAD may be the most appropriate reference for controlling UA in HD patients.
BACKGROUND/AIMS: Uric acid (UA) levels are affected by changes in dialysis; however, the relationship between the pre- and postdialysis UA difference (UAD) and mortality remains unclear. METHODS: A total of 1,073 patients receiving maintenance hemodialysis (HD) were enrolled in this cohort study and followed up for 5 years. Patients were divided into quartile categories according to baseline UAD. Cox's regression analyses were used to investigate the relationship between UAD categories and all-cause and cardiovascular (CV) mortalities while adjusting for potential confounders. RESULTS: A total of 280 patients died of all causes, including 121 CV deaths, during the follow-up. In the analysis for all-cause mortality, hazard ratios were significantly higher in the lowest UAD group (< 4.7 mg/dL) than in the highest UAD group (> 6.2 mg/dL). A correlation was not observed with CV mortality. CONCLUSION:UAD correlated with all-cause mortality. UAD may be the most appropriate reference for controlling UA in HDpatients.