Hung-Yun Lin1,2,3,4, Heng-Yuan Tang5, Matthew Leinung6, Shaker A Mousa1, Aleck Hercbergs7, Paul J Davis1,6. 1. Taipei Cancer Center, Taipei Medical University , Taipei , Taiwan. 2. Graduate Institute for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University , Taipei , Taiwan. 3. Traditional Herbal Medicine Research Center of Taipei Medical University Hospital, Taipei Medical University , Taipei , Taiwan. 4. TMU Research Center of Cancer Translational Medicine, Taipei Medical University , Taipei , Taiwan. 5. Pharmacetuical Research Institute, Albany College of Pharmacy and Health Sciences , Rensselaer , NY , USA. 6. Department of Medicine, Albany Medical College , Albany , NY , USA. 7. Department of Radiation Oncology, Cleveland Clinic , Cleveland , OH , USA.
Abstract
Background: Reverse T3 (rT3; 3,3',5'-triiodo-L-thyronine) is widely regarded as an inactive naturally occurring analog of thyroid hormone. rT3 is known to bind to the thyroid hormone analog receptor on plasma membrane integrin αvβ3. This integrin is generously expressed by tumor cells and is the initiation site for the stimulation by L-thyroxine (T4) at physiological free concentrations on cancer cell proliferation. Results: In the present studies, we show that rT3 caused increases of proliferation in vitro of 50% to 80% (P < 0.05-0.001) of human breast cancer and glioblastoma cells. Conclusion: rT3 may be a host factor supporting cancer growth.
Background: Reverse T3 (rT3; 3,3',5'-triiodo-L-thyronine) is widely regarded as an inactive naturally occurring analog of thyroid hormone. rT3 is known to bind to the thyroid hormone analog receptor on plasma membrane integrin αvβ3. This integrin is generously expressed by tumor cells and is the initiation site for the stimulation by L-thyroxine (T4) at physiological free concentrations on cancer cell proliferation. Results: In the present studies, we show that rT3 caused increases of proliferation in vitro of 50% to 80% (P < 0.05-0.001) of humanbreast cancer and glioblastoma cells. Conclusion: rT3 may be a host factor supporting cancer growth.
Entities:
Keywords:
3,3',5’-triiodo-L-thyronine; Integrin αvβ3; L-thyroxine; breast cancer; glioblastoma
Authors: Valerie Anne Galton; Maria Elena Martinez; Julie A Dragon; Donald L St Germain; Arturo Hernandez Journal: Thyroid Date: 2020-09-16 Impact factor: 6.568
Authors: Shaker A Mousa; Aleck Hercbergs; Hung-Yun Lin; Kelly A Keating; Paul J Davis Journal: Front Endocrinol (Lausanne) Date: 2021-06-21 Impact factor: 5.555