Literature DB >> 30943011

Novel Quinolylnitrones Combining Neuroprotective and Antioxidant Properties.

Mourad Chioua1, Manuel Salgado-Ramos1,2, Daniel Diez-Iriepa1, Alejandro Escobar-Peso1,2, Isabel Iriepa3, Dimitra Hadjipavlou-Litina4, Emma Martínez-Alonso2, Alberto Alcázar2, José Marco-Contelles1.   

Abstract

We describe here the preparation, neuroprotective analysis, and antioxidant capacity of 11 novel quinolylnitrones (QN). The neuroprotective analysis of QN1-11 in an oxygen-glucose deprivation model, in primary neuronal cultures, has been determined, allowing us to identify QN6 as a very potent neuroprotective agent, showing significant high value at 0.5 and 10 μM (86.2%), a result in good agreement with the observed strong hydroxyl radical scavenger of QN6.

Entities:  

Keywords:  Antioxidants; cerebral ischemia; free radical scavengers; neuroprotection; quinolylnitrones; synthesis

Mesh：

Substances：

Year:  2019        PMID： 30943011     DOI： 10.1021/acschemneuro.9b00152

Source DB:  PubMed          Journal:  ACS Chem Neurosci        ISSN： 1948-7193            Impact factor:   4.418


  7 in total

1.  Epileptic brain fluorescent imaging reveals apigenin can relieve the myeloperoxidase-mediated oxidative stress and inhibit ferroptosis.

Authors:  Chenwen Shao; Jiwen Yuan; Yani Liu; Yajuan Qin; Xueao Wang; Jin Gu; Guiquan Chen; Bing Zhang; Hong-Ke Liu; Jing Zhao; Hai-Liang Zhu; Yong Qian
Journal:  Proc Natl Acad Sci U S A       Date:  2020-04-23       Impact factor: 11.205

2.  Preclinical Characterization of Antioxidant Quinolyl Nitrone QN23 as a New Candidate for the Treatment of Ischemic Stroke.

Authors:  Emma Martínez-Alonso; Alejandro Escobar-Peso; Alicia Aliena-Valero; Germán Torregrosa; Mourad Chioua; Rocío Fernández-Serra; Daniel González-Nieto; Youness Ouahid; Juan B Salom; Jaime Masjuan; José Marco-Contelles; Alberto Alcázar
Journal:  Antioxidants (Basel)       Date:  2022-06-16

3.  Synthesis, Neuroprotection, and Antioxidant Activity of 1,1'-Biphenylnitrones as α-Phenyl-N-tert-butylnitrone Analogues in In Vitro Ischemia Models.

Authors:  Beatriz Chamorro; David García-Vieira; Daniel Diez-Iriepa; Estíbaliz Garagarza; Mourad Chioua; Dimitra Hadjipavlou-Litina; Francisco López-Muñoz; José Marco-Contelles; María Jesús Oset-Gasque
Journal:  Molecules       Date:  2021-02-20       Impact factor: 4.411

4.  5-Aryl-2-(3,5-dialkyl-4-hydroxyphenyl)-4,4-dimethyl-4H-imidazole 3-Oxides and Their Redox Species: How Antioxidant Activity of 1-Hydroxy-2,5-dihydro-1H-imidazoles Correlates with the Stability of Hybrid Phenoxyl-Nitroxides.

Authors:  Svetlana A Amitina; Elena V Zaytseva; Natalya A Dmitrieva; Alyona V Lomanovich; Natalya V Kandalintseva; Yury A Ten; Ilya A Artamonov; Alexander F Markov; Dmitrii G Mazhukin
Journal:  Molecules       Date:  2020-07-08       Impact factor: 4.411

5.  Homo-Tris-Nitrones Derived from α-Phenyl-N-tert-butylnitrone: Synthesis, Neuroprotection and Antioxidant Properties.

Authors:  Daniel Diez-Iriepa; Beatriz Chamorro; Marta Talaván; Mourad Chioua; Isabel Iriepa; Dimitra Hadjipavlou-Litina; Francisco López-Muñoz; José Marco-Contelles; María Jesús Oset-Gasque
Journal:  Int J Mol Sci       Date:  2020-10-26       Impact factor: 5.923

6.  Synthesis, antioxidant properties and neuroprotection of α-phenyl-tert-butylnitrone derived HomoBisNitrones in in vitro and in vivo ischemia models.

Authors:  Beatriz Chamorro; Daniel Diez-Iriepa; Belén Merás-Sáiz; Mourad Chioua; David García-Vieira; Isabel Iriepa; Dimitra Hadjipavlou-Litina; Francisco López-Muñoz; Ricardo Martínez-Murillo; Daniel Gonzàlez-Nieto; Israel Fernández; José Marco-Contelles; María Jesús Oset-Gasque
Journal:  Sci Rep       Date:  2020-08-25       Impact factor: 4.379

Review 7.  Antioxidant for Neurological Diseases and Neurotrauma and Bioengineering Approaches.

Authors:  Nasera Rizwana; Vipul Agarwal; Manasa Nune
Journal:  Antioxidants (Basel)       Date:  2021-12-29
  7 in total

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