Marta Tagliabue1, Sara Gandini2, Fausto Maffini3, Valeria Navach1, Roberto Bruschini1, Gioacchino Giugliano1, Francesca Lombardi4, Susanna Chiocca2, Elisabetta Rebecchi5, Eleonora Sica6, Massimo Tommasino7, Luca Calabrese1, Mohssen Ansarin1. 1. Division of Otolaryngology and Head and Neck Surgery, European Institute of Oncology IRCCS, Milan, Italy. 2. Department of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy. 3. Division of Pathology, European Institute of Oncology IRCCS, Milan, Italy. 4. Division of Data Manager, European Institute of Oncology IRCCS, Milan, Italy. 5. Department of Otolaryngology Head Neck Surgery, University of Pavia, IRCCS Policlinico San Matteo Foundation, Pavia, Italy. 6. Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, ASST Sette Laghi, Ospedale di circolo Fondazione Macchi, Varese, Italy. 7. Infections and Cancer Biology Group, International Agency for Research on Cancer, Course Albert Thomas 150, Lyon, France.
Abstract
BACKGROUND: We investigated the role of the soft tissue tract between the primary tumor and the neck lymph nodes, the "T-N tract," in patients with tongue squamous cell carcinoma at an advanced stage. METHODS: We performed a compartmental tongue surgery in 233 patients. Cumulative incidence of relapses and overall survival curves were compared by T-N tract involvement. Multivariate Cox proportional hazards models were used to assess the independent role of T-N tract. RESULTS: At 4 years of follow-up, patients with disease in the T-N tract experienced a significantly more distant recurrence (40%) than did patients without T-N tract involvement (22%; P = .02). Multivariate Cox models indicate a significant almost triple risk of distant metastases (hazard ratio [HR], 2.70; 95% CI, 1.01-7.19; P = .05) and double risk of death (HR, 2.09; 95%CI, 1.13-3.85; P = .02) in patients with "T-N tract involvement." CONCLUSIONS: Our data show that the T-N tract plays an important role in prognosis and survival in patients with tongue cancer.
BACKGROUND: We investigated the role of the soft tissue tract between the primary tumor and the neck lymph nodes, the "T-N tract," in patients with tongue squamous cell carcinoma at an advanced stage. METHODS: We performed a compartmental tongue surgery in 233 patients. Cumulative incidence of relapses and overall survival curves were compared by T-N tract involvement. Multivariate Cox proportional hazards models were used to assess the independent role of T-N tract. RESULTS: At 4 years of follow-up, patients with disease in the T-N tract experienced a significantly more distant recurrence (40%) than did patients without T-N tract involvement (22%; P = .02). Multivariate Cox models indicate a significant almost triple risk of distant metastases (hazard ratio [HR], 2.70; 95% CI, 1.01-7.19; P = .05) and double risk of death (HR, 2.09; 95%CI, 1.13-3.85; P = .02) in patients with "T-N tract involvement." CONCLUSIONS: Our data show that the T-N tract plays an important role in prognosis and survival in patients with tongue cancer.
Authors: Alberto Grammatica; Cesare Piazza; Marco Ferrari; Vincenzo Verzeletti; Alberto Paderno; Davide Mattavelli; Alberto Schreiber; Davide Lombardi; Enrico Fazio; Luca Gazzini; Giovanni Giorgetti; Barbara Buffoli; Luigi Fabrizio Rodella; Piero Nicolai; Luca Calabrese Journal: Front Oncol Date: 2021-04-23 Impact factor: 6.244
Authors: Luca Calabrese; Maria Eleonora Bizzoca; Roberto Grigolato; Fausto Antonio Maffini; Marta Tagliabue; Rosa Negro; Stefania Leuci; Michele Davide Mignogna; Lorenzo Lo Muzio Journal: Life (Basel) Date: 2020-09-12