| Literature DB >> 30942567 |
Guang Yang1,2,3,4, Qian Chen1,2,3, Di Wen1,2,3, Zhaowei Chen1,2,3, Jinqiang Wang1,2,3, Guojun Chen1,2,3, Zejun Wang1,2, Xudong Zhang1,2,3, Yuqi Zhang1,3, Quanyin Hu1,3, Liang Zhang5,6,7, Zhen Gu1,2,3.
Abstract
Activating hair follicle stem cells (HFSCs) to promote hair follicle regrowth holds promise for hair loss therapy, while challenges still remain to develop a scenario that enables enhanced therapeutic efficiency and easy administration. Here we describe a detachable microneedle patch-mediated drug delivery system, mainly made from hair-derived keratin, for sustained delivery of HFSC activators. It was demonstrated that this microneedle device integrated with mesenchymal stem cell (MSC)-derived exosomes and a small molecular drug, UK5099, could enhance the treatment efficiency at a reduced dosage, leading to promoted pigmentation and hair regrowth within 6 days through two rounds of administration in a mouse model. This microneedle-based transdermal drug delivery approach shows augmented efficacy compared to the subcutaneous injection of exosomes and topical administration of UK5099.Entities:
Keywords: drug delivery; exosome; hair regrowth; keratin; microneedle; transdermal drug delivery
Year: 2019 PMID： 30942567 DOI： 10.1021/acsnano.8b09573
Source DB: PubMed Journal: ACS Nano ISSN： 1936-0851 Impact factor: 15.881