Asieh Sadeghi1, Raheleh Roudi1, Alireza Mirzaei2, Ali Zare Mirzaei3, Zahra Madjd1,4, Maryam Abolhasani1,5. 1. Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran. 2. Bone & Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran. 3. Department of Pathology, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran. 4. Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran. 5. Department of Pathology, Hasheminejad Kidney Center, Iran University of Medical Sciences, Tehran, Iran.
Abstract
Aim: There is no consensus regarding the clinical significance of CD44 and CD24 as cancer stem cell (CSC) marker in colorectal cancer (CRC). Methodology: A total of 494 CRC samples (2008-2017) were assessed for CD44 (epithelial isoform) and CD24 expression using tissue microarray. Results: CD24 individually or in combination with CD44 was not associated with any of the clinicopathologic characteristics of the tumor. CD44 expression was inversely associated with pathological Tumor, Node, Metastasis (pTNM) lower stages (p = 0.038) and lymphatic invasion (p = 0.05). Conclusion: In summary, the epithelial isoform of CD44 is inversely associated with invasive characteristics of CRC.
Aim: There is no consensus regarding the clinical significance of CD44 and CD24 as cancer stem cell (CSC) marker in colorectal cancer (CRC). Methodology: A total of 494 CRC samples (2008-2017) were assessed for CD44 (epithelial isoform) and CD24 expression using tissue microarray. Results:CD24 individually or in combination with CD44 was not associated with any of the clinicopathologic characteristics of the tumor. CD44 expression was inversely associated with pathological Tumor, Node, Metastasis (pTNM) lower stages (p = 0.038) and lymphatic invasion (p = 0.05). Conclusion: In summary, the epithelial isoform of CD44 is inversely associated with invasive characteristics of CRC.
Entities:
Keywords:
CD24; CD44; cancer stem cell; clinical significance of CD44 and CD24 in colorectal cancer; colorectal cancer; colorectal cancer stem cells; combined analysis; epithelial isoform; epithelial isoform of CD44; immunohistochemistry; invasion; tissue microarray