Yoshito Tomimaru1, Sung Ae Park2, Asuka Shibata3, Shinichi Miyagawa3, Kozo Noguchi2, Shingo Noura2, Hiroshi Imamura2, Toru Shirakawa4, Keizo Dono2. 1. Department of Surgery, Toyonaka Municipal Hospital, 4-14-1 Shibahara, Toyonaka, Osaka, 560-8565, Japan. ytomimaru@gmail.com. 2. Department of Surgery, Toyonaka Municipal Hospital, 4-14-1 Shibahara, Toyonaka, Osaka, 560-8565, Japan. 3. Department of Psychiatry, Toyonaka Municipal Hospital, Toyonaka, Japan. 4. Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
Abstract
BACKGROUND: Postoperative delirium is a common serious complication after various types of surgery. However, the incidence and predictive factors associated with delirium after pancreaticoduodenectomy (PD) have not been investigated. Thus, this study aimed to investigate the incidence and predictive factors of postoperative delirium in patients who underwent PD. METHODS: This study included 155 consecutive patients who underwent PD. Patients with and without postoperative delirium were compared to identify differential patient characteristics. Multivariate regression analysis was used to statistically identify independent predictive factors significantly associated with the development of postoperative delirium. RESULTS: Postoperative delirium developed in 27 (22.4%) of 155 patients. The majority of incidents occurred on postoperative day 2, and the mean delirium duration was 4.6 ± 4.8 days. Patients with postoperative delirium had an older age and a previous history of benzodiazepine use. A multivariate analysis revealed that the development of delirium was significantly correlated with these two factors. Receiver-operator characteristics (ROC) curve analysis of the two factors yielded an area under the ROC curve of 0.823 (0.750-0.896), suggesting good discrimination power. CONCLUSIONS: This study reports on the incidence of postoperative delirium after PD. Furthermore, we identified age and use of benzodiazepines as significant predictive factors for developing delirium after PD. These results contribute to the prediction and treatment of postoperative delirium.
BACKGROUND:Postoperative delirium is a common serious complication after various types of surgery. However, the incidence and predictive factors associated with delirium after pancreaticoduodenectomy (PD) have not been investigated. Thus, this study aimed to investigate the incidence and predictive factors of postoperative delirium in patients who underwent PD. METHODS: This study included 155 consecutive patients who underwent PD. Patients with and without postoperative delirium were compared to identify differential patient characteristics. Multivariate regression analysis was used to statistically identify independent predictive factors significantly associated with the development of postoperative delirium. RESULTS:Postoperative delirium developed in 27 (22.4%) of 155 patients. The majority of incidents occurred on postoperative day 2, and the mean delirium duration was 4.6 ± 4.8 days. Patients with postoperative delirium had an older age and a previous history of benzodiazepine use. A multivariate analysis revealed that the development of delirium was significantly correlated with these two factors. Receiver-operator characteristics (ROC) curve analysis of the two factors yielded an area under the ROC curve of 0.823 (0.750-0.896), suggesting good discrimination power. CONCLUSIONS: This study reports on the incidence of postoperative delirium after PD. Furthermore, we identified age and use of benzodiazepines as significant predictive factors for developing delirium after PD. These results contribute to the prediction and treatment of postoperative delirium.
Authors: Frederik J van der Sluis; Pieter L Buisman; Mark Meerdink; Wouter B Aan de Stegge; Boudewijn van Etten; Geertruida H de Bock; Barbara L van Leeuwen; Robert A Pol Journal: Surgery Date: 2016-10-27 Impact factor: 3.982
Authors: James L Rudolph; Viken L Babikian; Vladimir Birjiniuk; Michael D Crittenden; Patrick R Treanor; Val E Pochay; Shukri F Khuri; Edward R Marcantonio Journal: J Am Geriatr Soc Date: 2005-03 Impact factor: 5.562
Authors: E R Marcantonio; G Juarez; L Goldman; C M Mangione; L E Ludwig; L Lind; N Katz; E F Cook; E J Orav; T H Lee Journal: JAMA Date: 1994-11-16 Impact factor: 56.272
Authors: E R Marcantonio; L Goldman; C M Mangione; L E Ludwig; B Muraca; C M Haslauer; M C Donaldson; A D Whittemore; D J Sugarbaker; R Poss Journal: JAMA Date: 1994-01-12 Impact factor: 56.272