Christian Trummer1, Verena Theiler-Schwetz2, Martina Kollmann3, Monika Wölfler4, Julia Münzker5, Stefan Pilz6, Thomas R Pieber7, Annemieke C Heijboer8, Barbara Obermayer-Pietsch9, Elisabeth Lerchbaum10. 1. Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria. Electronic address: christian.trummer@medunigraz.at. 2. Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria. Electronic address: verena.schwetz@medunigraz.at. 3. Department of Obstetrics and Gynecology, Division of Gynecological Endocrinology and Reproductive Medicine, Medical University of Graz, Auenbruggerplatz 14, 8036, Graz, Austria. Electronic address: martina.kollmann@medunigraz.at. 4. Department of Obstetrics and Gynecology, Division of Gynecological Endocrinology and Reproductive Medicine, Medical University of Graz, Auenbruggerplatz 14, 8036, Graz, Austria. Electronic address: monika.woelfler@medunigraz.at. 5. Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria; Department of Medicine, Integrated Research and Treatment Centre for Adiposity Diseases, Leipzig University, Philipp-Rosenthal-Straße 27, 04103, Leipzig, Germany. Electronic address: Julia.Muenzker@medizin.uni-leipzig.de. 6. Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria. Electronic address: stefan.pilz@medunigraz.at. 7. Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria. Electronic address: thomas.pieber@medunigraz.at. 8. Amsterdam UMC, Vrije Universiteit Amsterdam, Endocrine Laboratory, Department of Clinical Chemistry, De Boelelaan 1117, 1081, HV, Amsterdam, the Netherlands; Amsterdam UMC, University of Amsterdam, Laboratory of Endocrinology, Department of Clinical Chemistry, Meibergdreef 9, 1105, AZ, Amsterdam, the Netherlands. Electronic address: a.heijboer@vumc.nl. 9. Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria. Electronic address: barbara.obermayer@medunigraz.at. 10. Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria. Electronic address: elisabeth.lerchbaum@medunigraz.at.
Abstract
BACKGROUND & AIMS:Vitamin D supplementation may affect glycemic as well as hormonal regulation. Thus, the aim of the current study was to investigate whether vitamin D supplementation has any significant effects on metabolic and endocrine parameters in healthy premenopausal women. Primary outcome measure was the plasma glucose area under the curve (AUCgluc). METHODS: The current study was a single-center, double-blind, randomized placebo-controlled trial that was conducted at the Medical University of Graz, Austria, between March 2013 and October 2017. One-hundred and fifty healthy premenopausal women with 25-hydroxyvitamin D [25(OH)D] concentrations <75 nmol/L once weekly received either 20,000 IU of cholecalciferol or placebo (2:1 ratio) over a total of 24 weeks. RESULTS: In total, 127 women [age 36.2 ± 8.7 years; BMI 25.3 ± 5.6 kg/m2; baseline 25(OH)D 55.8 ± 19.7 nmol/L] completed the study. Vitamin D supplementation had no significant effect on AUCgluc (mean treatment effect 11.70; p = 0.069), while it had a significant treatment effect on homeostatic model assessment-insulin resistance (HOMA-IR; mean treatment effect 0.31; p = 0.019) and quantitative insulin-sensitivity check index (QUICKI; mean treatment effect -0.019; p = 0.013). There was no significant effect on the remaining secondary outcome parameters. CONCLUSIONS: In this randomized-controlled trial in healthy premenopausal women, there was a significant treatment effect of vitamin D supplementation on HOMA-IR and QUICKI, while there was no significant treatment effect on AUCgluc.
RCT Entities:
BACKGROUND & AIMS:Vitamin D supplementation may affect glycemic as well as hormonal regulation. Thus, the aim of the current study was to investigate whether vitamin D supplementation has any significant effects on metabolic and endocrine parameters in healthy premenopausal women. Primary outcome measure was the plasma glucose area under the curve (AUCgluc). METHODS: The current study was a single-center, double-blind, randomized placebo-controlled trial that was conducted at the Medical University of Graz, Austria, between March 2013 and October 2017. One-hundred and fifty healthy premenopausal women with 25-hydroxyvitamin D [25(OH)D] concentrations <75 nmol/L once weekly received either 20,000 IU of cholecalciferol or placebo (2:1 ratio) over a total of 24 weeks. RESULTS: In total, 127 women [age 36.2 ± 8.7 years; BMI 25.3 ± 5.6 kg/m2; baseline 25(OH)D 55.8 ± 19.7 nmol/L] completed the study. Vitamin D supplementation had no significant effect on AUCgluc (mean treatment effect 11.70; p = 0.069), while it had a significant treatment effect on homeostatic model assessment-insulin resistance (HOMA-IR; mean treatment effect 0.31; p = 0.019) and quantitative insulin-sensitivity check index (QUICKI; mean treatment effect -0.019; p = 0.013). There was no significant effect on the remaining secondary outcome parameters. CONCLUSIONS: In this randomized-controlled trial in healthy premenopausal women, there was a significant treatment effect of vitamin D supplementation on HOMA-IR and QUICKI, while there was no significant treatment effect on AUCgluc.
Authors: Elisabeth Lerchbaum; Christian Trummer; Verena Theiler-Schwetz; Martina Kollmann; Monika Wölfler; Stefan Pilz; Barbara Obermayer-Pietsch Journal: Nutrients Date: 2019-08-14 Impact factor: 5.717
Authors: Elisabeth Lerchbaum; Verena Theiler-Schwetz; Martina Kollmann; Monika Wölfler; Stefan Pilz; Barbara Obermayer-Pietsch; Christian Trummer Journal: Nutrients Date: 2021-02-07 Impact factor: 5.717