Literature DB >> 30939897

Identifying, linking, and treating people who inject drugs and were recently infected with HIV in the context of a network-based intervention.

Mina Psichogiou1, George Giallouros2, Katerina Pantavou2, Eirini Pavlitina3, Martha Papadopoulou1, Leslie D Williams4, Andria Hadjikou2,5, Eleni Kakalou6, Athanasios Skoutelis6, Konstantinos Protopapas7, Anastasia Antoniadou7, George Boulmetis8, Dimitrios Paraskevis9, Angelos Hatzakis9, Samuel R Friedman4, Georgios K Nikolopoulos2.   

Abstract

Identifying and linking people to care soon after HIV infection could limit viral transmission and protect their health. This work aims at describing the continuum of care among recently HIV-infected people who inject drugs (PWID) and participated in an intervention in the context of an HIV outbreak in Athens, Greece. The Transmission Reduction Intervention Project (TRIP) conducted risk network-based contact tracing and screened people for recent HIV infection. A comprehensive approach with a case management component that aimed to remove barriers to accessing care was adopted. Follow-up data on antiretroviral treatment (ART) and HIV-RNA levels were obtained from HIV clinics. TRIP enrolled 45 recently HIV-infected PWID (80% male) with a median viral load at recruitment of 5.43 log10 copies/mL. Of the recently infected persons in TRIP, 87% were linked to care; of these, 77% started ART; and of those on ART, 89% achieved viral load <200 copies/mL. TRIP and its public health allies managed to get most of the recently HIV-infected PWID who were identified by the program into care and many of them onto ART. This resulted in very low HIV-RNA levels. Treatment as prevention can work if individuals are aided in overcoming difficulties in entry to, or attrition from care.

Entities:  

Keywords:  Continuum of care; HIV; outbreak; recent HIV infection; social network; treatment cascade

Mesh:

Substances:

Year:  2019        PMID: 30939897      PMCID: PMC6818705          DOI: 10.1080/09540121.2019.1601671

Source DB:  PubMed          Journal:  AIDS Care        ISSN: 0954-0121


  52 in total

Review 1.  HIV treatment as prevention among injection drug users.

Authors:  Evan Wood; Michael John Milloy; Julio S G Montaner
Journal:  Curr Opin HIV AIDS       Date:  2012-03       Impact factor: 4.283

2.  Antiretroviral use among active injection-drug users: the role of patient-provider engagement and structural factors.

Authors:  Amy R Knowlton; Julia H Arnsten; Lois J Eldred; James D Wilkinson; Starley B Shade; Amy S Bohnert; Cui Yang; Lawrence S Wissow; David W Purcell
Journal:  AIDS Patient Care STDS       Date:  2010-07       Impact factor: 5.078

3.  Partner services in adults with acute and early HIV infection.

Authors:  Nella Green; Martin Hoenigl; Antoine Chaillon; Christy M Anderson; Sergei L Kosakovsky Pond; Davey M Smith; Susan J Little
Journal:  AIDS       Date:  2017-01-14       Impact factor: 4.177

4.  Evaluation of the limiting antigen avidity EIA (LAg) in people who inject drugs in Greece.

Authors:  G K Nikolopoulos; A Katsoulidou; M Kantzanou; C Rokka; C Tsiara; V Sypsa; D Paraskevis; M Psichogiou; S Friedman; A Hatzakis
Journal:  Epidemiol Infect       Date:  2016-10-26       Impact factor: 2.451

5.  Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection.

Authors:  Jens D Lundgren; Abdel G Babiker; Fred Gordin; Sean Emery; Birgit Grund; Shweta Sharma; Anchalee Avihingsanon; David A Cooper; Gerd Fätkenheuer; Josep M Llibre; Jean-Michel Molina; Paula Munderi; Mauro Schechter; Robin Wood; Karin L Klingman; Simon Collins; H Clifford Lane; Andrew N Phillips; James D Neaton
Journal:  N Engl J Med       Date:  2015-07-20       Impact factor: 91.245

6.  Adherence and plasma HIV RNA responses to highly active antiretroviral therapy among HIV-1 infected injection drug users.

Authors:  Evan Wood; Julio S G Montaner; Benita Yip; Mark W Tyndall; Martin T Schechter; Michael V O'Shaughnessy; Robert S Hogg
Journal:  CMAJ       Date:  2003-09-30       Impact factor: 8.262

7.  Factors linked to transitions in adherence to antiretroviral therapy among HIV-infected illicit drug users in a Canadian setting.

Authors:  Brenden Joseph; Thomas Kerr; Cathy M Puskas; Julio Montaner; Evan Wood; M-J Milloy
Journal:  AIDS Care       Date:  2015-04-27

8.  Methadone maintenance therapy decreases the rate of antiretroviral therapy discontinuation among HIV-positive illicit drug users.

Authors:  H Reddon; M-J Milloy; A Simo; J Montaner; E Wood; T Kerr
Journal:  AIDS Behav       Date:  2014-04

9.  Socially-integrated transdisciplinary HIV prevention.

Authors:  Samuel R Friedman; Martin J Downing; Pavlo Smyrnov; Georgios Nikolopoulos; John A Schneider; Britt Livak; Gkikas Magiorkinis; Liudmyla Slobodianyk; Tetyana I Vasylyeva; Dimitrios Paraskevis; Mina Psichogiou; Vana Sypsa; Melpomeni M Malliori; Angelos Hatzakis
Journal:  AIDS Behav       Date:  2014-10

10.  The Human Immunodeficiency Virus Continuum of Care in European Union Countries in 2013: Data and Challenges.

Authors:  Annabelle Gourlay; Teymur Noori; Anastasia Pharris; Maria Axelsson; Dominique Costagliola; Susan Cowan; Sara Croxford; Antonella d'Arminio Monforte; Julia Del Amo; Valerie Delpech; Asunción Díaz; Enrico Girardi; Barbara Gunsenheimer-Bartmeyer; Victoria Hernando; Sophie Jose; Gisela Leierer; Georgios Nikolopoulos; Niels Obel; Eline Op de Coul; Dimitra Paraskeva; Peter Reiss; Caroline Sabin; André Sasse; Daniela Schmid; Anders Sonnerborg; Alexander Spina; Barbara Suligoi; Virginie Supervie; Giota Touloumi; Dominique Van Beckhoven; Ard van Sighem; Georgia Vourli; Robert Zangerle; Kholoud Porter
Journal:  Clin Infect Dis       Date:  2017-06-15       Impact factor: 9.079

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  2 in total

1.  Experiences of Stigma and Support Reported by Participants in a Network Intervention to Reduce HIV Transmission in Athens, Greece; Odessa, Ukraine; and Chicago, Illinois.

Authors:  Leslie D Williams; A Korobchuk; E Pavlitina; G K Nikolopoulos; B Skaathun; J Schneider; E-G Kostaki; P Smyrnov; T I Vasylyeva; M Psichogiou; D Paraskevis; E Morgan; A Hadjikou; M J Downing; A Hatzakis; S R Friedman
Journal:  AIDS Behav       Date:  2019-05

2.  Drug Injection-Related and Sexual Behavior Changes in Drug Injecting Networks after the Transmission Reduction Intervention Project (TRIP): A Social Network-Based Study in Athens, Greece.

Authors:  George Giallouros; Katerina Pantavou; Despina Pampaka; Eirini Pavlitina; Daniele Piovani; Stefanos Bonovas; Georgios K Nikolopoulos
Journal:  Int J Environ Res Public Health       Date:  2021-03-01       Impact factor: 3.390

  2 in total

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