Katarzyna Ożga1, Magdalena Krzyczkowska-Sendrakowska2, Alicja Hubalewska-Dydejczyk3, Aleksandra Gilis-Januszewska3, Maciej Ratajczak4, Magdalena Ratajczak5, Zlata Chaykivska6, Robert Jach2. 1. Department of Gynaecological Endocrinology and Gynaecology, Jagiellonian University Medical College, Cracow, Poland. katharina.ozga@gmail.com. 2. Department of Gynaecological Endocrinology and Gynaecology, Jagiellonian University Medical College, Cracow, Poland. 3. Chair and Department of Endocrinology, Jagiellonian University Medical College, Cracow, Poland. 4. Department of Endocrinology, Medical Centre of Postgraduate Education, Bielański Hospital in Warsaw, Poland. 5. Public Central Teaching Clinical Hospital in Warsaw, Poland. 6. Clinical Department of Metabolic Diseases, Jagiellonian University Medical College, Cracow, Poland.
Abstract
INTRODUCTION: The free androgen index (FAI) values differ among patients with polycystic ovarian syndrome; however, the differences are not fully understood or known. The aim of the study was to evaluate FAI in women with polycystic ovary syndrome (PCOS) in regard to the phenotype of the PCOS and insulin resistance status. MATERIAL AND METHODS: Anthropometric, hormonal, and biochemical parameters were assessed in 312 recruited women with PCOS. The FAI values were calculated in the reproductive and metabolic phenotypes of PCOS in groups of insulin resistance status based on the homeostasis model assessment-insulin resistance (HOMA-IR) > 2.0 or fasting insulin (FI) > 10 mmol/L. To test the relationship between individual variables, Spearman's correlation analysis, the Kolmogorov-Smirnov test, and Student's t-test were used. RESULTS: The correlation between FAI values and HOMA-IR and FI was 0.42 and 0.47, respectively, in PCOS patients. A two fold higher FAI value was observed in metabolic PCOS phenotype when compared to the reproductive one (8.51 ± 5.56 vs. 4.40 ± 2.45 for HOMA-IR and 8.73 ± 6.09 vs. 4.31 ± 3.39 for FI, respectively; p < 0.05). CONCLUSIONS: PCOS patients are not a homogenous group in terms of FAI value. Patients with metabolic PCOS phenotype are characterised by two-fold higher FAI values compared with reproductive PCOS phenotype. Further studies on the metabolic and androgenic status of different types of PCOS phenotypes should be carried out.
INTRODUCTION: The free androgen index (FAI) values differ among patients with polycystic ovarian syndrome; however, the differences are not fully understood or known. The aim of the study was to evaluate FAI in women with polycystic ovary syndrome (PCOS) in regard to the phenotype of the PCOS and insulin resistance status. MATERIAL AND METHODS: Anthropometric, hormonal, and biochemical parameters were assessed in 312 recruited women with PCOS. The FAI values were calculated in the reproductive and metabolic phenotypes of PCOS in groups of insulin resistance status based on the homeostasis model assessment-insulin resistance (HOMA-IR) > 2.0 or fasting insulin (FI) > 10 mmol/L. To test the relationship between individual variables, Spearman's correlation analysis, the Kolmogorov-Smirnov test, and Student's t-test were used. RESULTS: The correlation between FAI values and HOMA-IR and FI was 0.42 and 0.47, respectively, in PCOSpatients. A two fold higher FAI value was observed in metabolic PCOS phenotype when compared to the reproductive one (8.51 ± 5.56 vs. 4.40 ± 2.45 for HOMA-IR and 8.73 ± 6.09 vs. 4.31 ± 3.39 for FI, respectively; p < 0.05). CONCLUSIONS:PCOSpatients are not a homogenous group in terms of FAI value. Patients with metabolic PCOS phenotype are characterised by two-fold higher FAI values compared with reproductive PCOS phenotype. Further studies on the metabolic and androgenic status of different types of PCOS phenotypes should be carried out.
Authors: Małgorzata Kałużna; Tomasz Krauze; Katarzyna Ziemnicka; Katarzyna Wachowiak-Ochmańska; Jolanta Kaczmarek; Adam Janicki; Andrzej Wykrętowicz; Marek Ruchała; Przemysław Guzik Journal: Endocrine Date: 2021-02-22 Impact factor: 3.633