Chronic Fatigue Syndrome, Functional Mitochondriopathy, and Enterohepatic Dysfunction.

Chronic fatigue syndrome (CFS) has remained a medical enigma since it was first reported in the late 1980s by Paul Cheney, MD, PhD, who-along with his medical partner in Incline Village, Nevada-made the observation of a group of his patients all having serious and unremitting fatigue following a significant winter flu season. I was introduced to Dr Cheney by Scott Rigden, MD, an expert in the study of chronic fatigue syndrome and also a key advisor to me during the founding days of the Institute for Functional Medicine. From 1989 to 1991, Dr Cheney was an important contributor to the development of concepts underlying the Functional Medicine model.