Literature DB >> 30936511

First targeted protein degrader hits the clinic.

Asher Mullard.   

Abstract

Keywords:  Drug discovery

Year:  2019        PMID： 30936511     DOI： 10.1038/d41573-019-00043-6

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


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  31 in total

Review 1.  Regulation of large and small G proteins by ubiquitination.

Authors:  Henrik G Dohlman; Sharon L Campbell
Journal:  J Biol Chem       Date:  2019-10-23       Impact factor: 5.157

2.  Polyubiquitin Chains Linked by Lysine Residue 48 (K48) Selectively Target Oxidized Proteins In Vivo.

Authors:  Sandhya Manohar; Samson Jacob; Jade Wang; Keira A Wiechecki; Hiromi W L Koh; Vanessa Simões; Hyungwon Choi; Christine Vogel; Gustavo M Silva
Journal:  Antioxid Redox Signal       Date:  2019-11-20       Impact factor: 8.401

3.  A Nimbolide-Based Kinase Degrader Preferentially Degrades Oncogenic BCR-ABL.

Authors:  Bingqi Tong; Jessica N Spradlin; Luiz F T Novaes; Erika Zhang; Xirui Hu; Malte Moeller; Scott M Brittain; Lynn M McGregor; Jeffrey M McKenna; John A Tallarico; Markus Schirle; Thomas J Maimone; Daniel K Nomura
Journal:  ACS Chem Biol       Date:  2020-06-25       Impact factor: 5.100

Review 4.  Targeted protein degradation in antibacterial drug discovery?

Authors:  Pooja Gopal; Thomas Dick
Journal:  Prog Biophys Mol Biol       Date:  2019-11-16       Impact factor: 3.667

5.  Strategies toward Discovery of Potent and Orally Bioavailable Proteolysis Targeting Chimera Degraders of Androgen Receptor for the Treatment of Prostate Cancer.

Authors:  Xin Han; Lijie Zhao; Weiguo Xiang; Chong Qin; Bukeyan Miao; Donna McEachern; Yu Wang; Hoda Metwally; Lu Wang; Aleksas Matvekas; Bo Wen; Duxin Sun; Shaomeng Wang
Journal:  J Med Chem       Date:  2021-08-25       Impact factor: 7.446

6.  Selective Degradation of GSPT1 by Cereblon Modulators Identified via a Focused Combinatorial Library.

Authors:  Chelsea E Powell; Guangyan Du; Jianwei Che; Zhixiang He; Katherine A Donovan; Hong Yue; Eric S Wang; Radosław P Nowak; Tinghu Zhang; Eric S Fischer; Nathanael S Gray
Journal:  ACS Chem Biol       Date:  2020-09-28       Impact factor: 5.100

7.  Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader.

Authors:  Frances Potjewyd; Anne-Marie W Turner; Joshua Beri; Justin M Rectenwald; Jacqueline L Norris-Drouin; Stephanie H Cholensky; David M Margolis; Kenneth H Pearce; Laura E Herring; Lindsey I James
Journal:  Cell Chem Biol       Date:  2019-12-09       Impact factor: 8.116

8.  Protein Arginine Methyltransferase 5 Promotes pICln-Dependent Androgen Receptor Transcription in Castration-Resistant Prostate Cancer.

Authors:  Shuyi Fang; Jake L Owens; Elena Beketova; Sheng Liu; Xufeng Chen; Qingfu Zhang; Andrew M Asberry; Xuehong Deng; Jonathan Malola; Jiaoti Huang; Chenglong Li; Roberto Pili; Bennett D Elzey; Timothy L Ratliff; Jun Wan; Chang-Deng Hu
Journal:  Cancer Res       Date:  2020-09-30       Impact factor: 12.701

Review 9.  Ubiquitination, Biotech Startups, and the Future of TRIM Family Proteins: A TRIM-Endous Opportunity.

Authors:  Utsa Bhaduri; Giuseppe Merla
Journal:  Cells       Date:  2021-04-25       Impact factor: 6.600

10.  Proteolysis Targeting Chimeras for BTK Efficiently Inhibit B-Cell Receptor Signaling and Can Overcome Ibrutinib Resistance in CLL Cells.

Authors:  Yamit Shorer Arbel; Ben-Zion Katz; Ronen Gabizon; Amit Shraga; Yotam Bronstein; Talia Kamdjou; Anat Globerson Levin; Chava Perry; Irit Avivi; Nir London; Yair Herishanu
Journal:  Front Oncol       Date:  2021-05-13       Impact factor: 6.244
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