| Literature DB >> 30936486 |
Harshad Ingle1, Sanghyun Lee2, Teresa Ai1, Anthony Orvedahl3, Rachel Rodgers3, Guoyan Zhao2, Meagan Sullender1, Stefan T Peterson1, Marissa Locke2, Ta-Chiang Liu2, Christine C Yokoyama2, Bridgett Sharp4, Stacey Schultz-Cherry4, Jonathan J Miner1,2,5, Megan T Baldridge6,7.
Abstract
Commensal microbes profoundly impact host immunity to enteric viral infections1. We have shown that the bacterial microbiota and host antiviral cytokine interferon-λ (IFN-λ) determine the persistence of murine norovirus in the gut2,3. However, the effects of the virome in modulating enteric infections remain unexplored. Here, we report that murine astrovirus can complement primary immunodeficiency to protect against murine norovirus and rotavirus infections. Protection against infection was horizontally transferable between immunocompromised mouse strains by co-housing and fecal transplantation. Furthermore, protection against enteric pathogens corresponded with the presence of a specific strain of murine astrovirus in the gut, and this complementation of immunodeficiency required IFN-λ signalling in gut epithelial cells. Our study demonstrates that elements of the virome can protect against enteric pathogens in an immunodeficient host.Entities:
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Year: 2019 PMID： 30936486 PMCID： PMC6588490 DOI： 10.1038/s41564-019-0416-7
Source DB: PubMed Journal: Nat Microbiol ISSN： 2058-5276 Impact factor: 17.745