Nevena Chakarova1, Rumyana Dimova2, Greta Grozeva2, Tsvetalina Tankova2. 1. Department of Diabetology, Clinical Center of Endocrinology and Gerontology, Medical University Sofia, Bulgaria. Electronic address: veni_chakarova@abv.bg. 2. Department of Diabetology, Clinical Center of Endocrinology and Gerontology, Medical University Sofia, Bulgaria.
Abstract
The aim of the study was to assess glucose variability in subjects with prediabetes by means of CGM. MATERIAL AND METHODS: 32 subjects with prediabetes - mean age 56.6 ± 9.6 years, mean BMI 30.3 ± 5.3 kg/m2 and 18 subjects with normal glucose tolerance (NGT) - mean age 54.4 ± 9.9 years, mean BMI 24.8 ± 6.9 kg/m2, were enrolled. Glucose tolerance was studied during OGTT. HbA1c was measured by NGSP certified method. CGM was performed with FreeStyle Libre Pro sensor. RESULTS: The following indices of glucose variability were significantly higher in the prediabetes group - CV (p < 0.041), J-index (p < 0.014), CONGA (p < 0.047) and GRADE (p < 0.036). A significant increase in HbA1c (p < 0.036), mean interstitial glucose (p < 0.025), time above range (p < 0.018) and a significant decrease in time in range (p < 0.014) was found in prediabetes compared to NGT. Significant correlations between HbA1c and LBGI (r = -0.33, p = 0.02), HBGI (r = 0.31, p = 0.03), CONGA (r = 0.36, p = 0.01), J-index (r = 0.37, p = 0.01) and M-value (r = -0.34, p = 0.02) were established. CONCLUSION: Glucose variability is significantly increased in prediabetes and is an additional parameter in the assessment of glucose homeostasis even at these early stages of glucose dysregulation.
The aim of the study was to assess glucose variability in subjects with prediabetes by means of CGM. MATERIAL AND METHODS: 32 subjects with prediabetes - mean age 56.6 ± 9.6 years, mean BMI 30.3 ± 5.3 kg/m2 and 18 subjects with normal glucose tolerance (NGT) - mean age 54.4 ± 9.9 years, mean BMI 24.8 ± 6.9 kg/m2, were enrolled. Glucose tolerance was studied during OGTT. HbA1c was measured by NGSP certified method. CGM was performed with FreeStyle Libre Pro sensor. RESULTS: The following indices of glucose variability were significantly higher in the prediabetes group - CV (p < 0.041), J-index (p < 0.014), CONGA (p < 0.047) and GRADE (p < 0.036). A significant increase in HbA1c (p < 0.036), mean interstitial glucose (p < 0.025), time above range (p < 0.018) and a significant decrease in time in range (p < 0.014) was found in prediabetes compared to NGT. Significant correlations between HbA1c and LBGI (r = -0.33, p = 0.02), HBGI (r = 0.31, p = 0.03), CONGA (r = 0.36, p = 0.01), J-index (r = 0.37, p = 0.01) and M-value (r = -0.34, p = 0.02) were established. CONCLUSION:Glucose variability is significantly increased in prediabetes and is an additional parameter in the assessment of glucose homeostasis even at these early stages of glucose dysregulation.
Authors: Kristine Færch; Martin B Blond; Lea Bruhn; Hanan Amadid; Dorte Vistisen; Kim K B Clemmensen; Camilla T R Vainø; Camilla Pedersen; Maria Tvermosegaard; Thomas F Dejgaard; Kristian Karstoft; Mathias Ried-Larsen; Frederik Persson; Marit E Jørgensen Journal: Diabetologia Date: 2020-10-16 Impact factor: 10.122
Authors: Su Hyun Park; Jiali Yao; Xin Hui Chua; Suresh Rama Chandran; Daphne S L Gardner; Chin Meng Khoo; Falk Müller-Riemenschneider; Clare Whitton; Rob M van Dam Journal: Nutrients Date: 2022-01-15 Impact factor: 5.717