Scott O Trerotola1, Gary A Pressler2, Christopher Premanandan3. 1. Department of Radiology, Division of Interventional Radiology, Hospital of the University of Pennsylvania, Perelman School of Medicine, 1 Silverstein, 3400 Spruce Street, Philadelphia, PA 19104. Electronic address: streroto@uphs.upenn.edu. 2. Cook Research Incorporated, West Lafayette, Indiana. 3. Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio.
Abstract
PURPOSE: To determine whether nylon fibers improve the performance of platinum embolization coils in porcine arteries. MATERIALS AND METHODS: Platinum 0.035" embolization coils, both with and without nylon fibers, were used to embolize a total of 24 hindlimb arteries in 6 swine: 12 with fibered coils and 12 with non-fibered coils. Apart from fibers, the coils were identical. Immediate and late results were studied, including number of coils needed to achieve vessel occlusion and durability of occlusion at 1 and 3 months. Arteriographic as well as histopathologic analysis were performed. RESULTS: A mean of 3.2 (range, 2-4) non-fibered coils was required to achieve occlusion, whereas a mean of 1.3 (range, 1-2) fibered coils achieved occlusion in similarly sized arteries (2.3-3.2-mm diameter, P < .001). The mean percent cross-sectional area occupied by thrombus was greater in arteries with fibered coils than with non-fibered coils at 1 month (63% ± 6% and 48% ± 15%, respectively, P = .03) but not at 3 months (61% ± 6% and 49% ± 15%, respectively, P = .06). Some recanalization was observed at follow-up and did not differ between groups at 1 month (P = .07) or 3 months (P = .22). CONCLUSIONS: Nylon fibers allow significantly fewer embolization coils to achieve acute occlusion of arteries compared to bare metal coils. Both fibered and non-fibered coils showed recanalization at follow-up.
PURPOSE: To determine whether nylon fibers improve the performance of platinum embolization coils in porcine arteries. MATERIALS AND METHODS:Platinum 0.035" embolization coils, both with and without nylon fibers, were used to embolize a total of 24 hindlimb arteries in 6 swine: 12 with fibered coils and 12 with non-fibered coils. Apart from fibers, the coils were identical. Immediate and late results were studied, including number of coils needed to achieve vessel occlusion and durability of occlusion at 1 and 3 months. Arteriographic as well as histopathologic analysis were performed. RESULTS: A mean of 3.2 (range, 2-4) non-fibered coils was required to achieve occlusion, whereas a mean of 1.3 (range, 1-2) fibered coils achieved occlusion in similarly sized arteries (2.3-3.2-mm diameter, P < .001). The mean percent cross-sectional area occupied by thrombus was greater in arteries with fibered coils than with non-fibered coils at 1 month (63% ± 6% and 48% ± 15%, respectively, P = .03) but not at 3 months (61% ± 6% and 49% ± 15%, respectively, P = .06). Some recanalization was observed at follow-up and did not differ between groups at 1 month (P = .07) or 3 months (P = .22). CONCLUSIONS: Nylon fibers allow significantly fewer embolization coils to achieve acute occlusion of arteries compared to bare metal coils. Both fibered and non-fibered coils showed recanalization at follow-up.