Literature DB >> 3093433

Ahpatinins, new acid protease inhibitors containing 4-amino-3-hydroxy-5-phenylpentanoic acid.

S Omura, N Imamura, K Kawakita, Y Mori, Y Yamazaki, R Masuma, Y Takahashi, H Tanaka, L Y Huang, H B Woodruff.   

Abstract

A soil isolate, Streptomyces sp. WK-142, was found to produce new acid protease inhibitors, ahpatinins A, B, D, E, F and G active against pepsin and renin. Ahpatinin C was found to be identical with pepstatin A. The structure determinations were based on mass spectral data. Four of the compounds contain the unusual amino acid, 4-amino-3-hydroxy-5-phenylpentanoic acid as a building component.

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Year:  1986        PMID: 3093433     DOI: 10.7164/antibiotics.39.1079

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN: 0021-8820            Impact factor:   2.649


  2 in total

Review 1.  Thom Award Lecture. Trends in the search for bioactive microbial metabolites.

Authors:  S Omura
Journal:  J Ind Microbiol       Date:  1992-09

2.  Ahmpatinin iBu, a new HIV-1 protease inhibitor, from Streptomyces sp. CPCC 202950.

Authors:  Ming-Hua Chen; Shan-Shan Chang; Biao Dong; Li-Yan Yu; Ye-Xiang Wu; Ren-Zhong Wang; Wei Jiang; Zeng-Ping Gao; Shu-Yi Si
Journal:  RSC Adv       Date:  2018-01-30       Impact factor: 4.036

  2 in total

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