| Literature DB >> 30933750 |
Di Chuan1, Tao Jin2, Rangrang Fan1, Liangxue Zhou1, Gang Guo3.
Abstract
Gene therapy is a promising strategy for treating challenging diseases. The successful delivery of genes is a critical step for gene therapy. However, concerns about immunogenicity and toxicity are the main obstacles against the widespread use of effective viral systems. Therefore, nonviral vectors are regarded as good alternatives to viral vectors. Chitosan is a natural cationic polysaccharide that could be used to create nonviral gene delivery vectors. Various methods have been developed to improve the properties of chitosan related to gene delivery. This review introduces the features of chitosan in gene delivery, summarizes current progress toward methods promoting the properties of chitosan related to gene delivery, and presents different applications of chitosan in gene delivery vectors. Finally, future prospects of gene vectors based on chitosan are discussed.Entities:
Keywords: Chitosan; Gene delivery; Gene therapy; Non-viral vector; Polysaccharide
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Year: 2019 PMID： 30933750 DOI： 10.1016/j.cis.2019.03.007
Source DB: PubMed Journal: Adv Colloid Interface Sci ISSN： 0001-8686 Impact factor: 12.984