Mario Turri-Zanoni1,2, Alessia Lambertoni1, Stefano Margherini1, Marta Giovannardi3, Marco Ferrari4, Vittorio Rampinelli4, Alberto Schreiber4, Mario Cherubino2,5, Paolo Antognoni6, Davide Locatelli2,7, Paolo Battaglia1,2, Paolo Castelnuovo1,2, Piero Nicolai4. 1. Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy. 2. Head and Neck Surgery & Forensic Dissection Research Center (HNS&FDRc), Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy. 3. Unit of Biostatistics, Department of Statistics, Monzino Hospital, Milan, Italy. 4. Division of Otorhinolaryngology, Spedali Civili di Brescia, University of Brescia, Brescia, Italy. 5. Division of Plastic and Reconstructive Surgery, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy. 6. Division of Radiation Oncology, University of Insubria, Varese, Italy. 7. Division of Neurosurgery, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.
Abstract
BACKGROUND: Sinonasal cancers frequently involve the orbit with resulting controversies on whether to remove or preserve the orbital contents. METHODS: Retrospective review of patients with primary sinonasal cancer involving the orbit, treated according to a multidisciplinary protocol tailored to tumor histology and extent of orbital invasion in two tertiary care referral centers over a 20-year period. RESULTS: The oncological and functional outcomes of 163 patients were analyzed. The degree of orbital involvement significantly affected both overall (P < .0001) and disease-free (P < .0001) survival. Orbital apex invasion was an independent negative prognostic factor (5-year overall survival, 14.6% ± 7.5%), with dismal prognosis regardless of the treatment adopted. An appropriate use of induction chemotherapy and endoscopic-assisted surgery allowed for orbital preservation in 76.6% of cases; 96% of patients treated using an orbit-sparing approach maintained a functional eye after treatment. CONCLUSION: The multimodal treatment algorithm herein proposed was able to maximize orbital preservation rates with acceptable oncological and functional outcomes.
BACKGROUND:Sinonasal cancers frequently involve the orbit with resulting controversies on whether to remove or preserve the orbital contents. METHODS: Retrospective review of patients with primary sinonasal cancer involving the orbit, treated according to a multidisciplinary protocol tailored to tumor histology and extent of orbital invasion in two tertiary care referral centers over a 20-year period. RESULTS: The oncological and functional outcomes of 163 patients were analyzed. The degree of orbital involvement significantly affected both overall (P < .0001) and disease-free (P < .0001) survival. Orbital apex invasion was an independent negative prognostic factor (5-year overall survival, 14.6% ± 7.5%), with dismal prognosis regardless of the treatment adopted. An appropriate use of induction chemotherapy and endoscopic-assisted surgery allowed for orbital preservation in 76.6% of cases; 96% of patients treated using an orbit-sparing approach maintained a functional eye after treatment. CONCLUSION: The multimodal treatment algorithm herein proposed was able to maximize orbital preservation rates with acceptable oncological and functional outcomes.
Authors: Alexander Maurer; Christian M Meerwein; Michael B Soyka; Hannes Grünig; Stephan Skawran; Urs J Mühlematter; Michael Messerli; Cäcilia E Mader; Lars Husmann; Niels J Rupp; David Holzmann; Martin W Huellner Journal: Head Neck Date: 2021-09-13 Impact factor: 3.821
Authors: Fernando López; Jatin P Shah; Jonathan J Beitler; Carl H Snyderman; Valerie Lund; Cesare Piazza; Antti A Mäkitie; Orlando Guntinas-Lichius; Juan P Rodrigo; Luiz P Kowalski; Miquel Quer; Ashok Shaha; Akihiro Homma; Alvaro Sanabria; Renata Ferrarotto; Anne W M Lee; Victor H F Lee; Alessandra Rinaldo; Alfio Ferlito Journal: Adv Ther Date: 2022-03-30 Impact factor: 4.070
Authors: Mario Cherubino; Tommaso Baroni; Veronica Santoro; Leonardo Garutti; Paolo Battaglia; Mario Turri-Zanoni; Pietro Di Summa; Federico Tamborini; Danilo di Giovanna; Luigi Valdatta Journal: Plast Reconstr Surg Glob Open Date: 2021-10-26
Authors: Christian M Meerwein; Panagiotis Balermpas; Domenic G Vital; Martina A Broglie; Michael B Soyka; David Holzmann Journal: Am J Rhinol Allergy Date: 2021-07-22 Impact factor: 2.467