| Literature DB >> 30930096 |
Natalia de M Lyra E Silva1, Rafaella Araujo Gonçalves1, Susan E Boehnke1, Leticia Forny-Germano2, Douglas P Munoz3, Fernanda G De Felice4.
Abstract
Alzheimer's disease (AD) is a devastating neurodegenerative disease affecting millions of people worldwide. AD is characterized by a profound impairment of higher cognitive functions and still lacks any effective disease-modifying treatment. Defective insulin signaling has been implicated in AD pathophysiology, but the mechanisms underlying this process are not fully understood. Here, we review the molecular mechanisms underlying defective brain insulin signaling in rodent models of AD, and in a non-human primate (NHP) model of the disease that recapitulates features observed in AD brains. We further highlight similarities between the NHP and human brains and discuss why NHP models of AD are important to understand disease mechanisms and to improve the translation of effective therapies to humans. We discuss how studies using different animal models have contributed to elucidate the link between insulin resistance and AD. CrownEntities:
Keywords: Alzheimer’s disease; Animal models; Cognitive control; Inflammation; Insulin; Insulin resistance
Mesh：
Year: 2019 PMID： 30930096 DOI： 10.1016/j.expneurol.2019.03.016
Source DB: PubMed Journal: Exp Neurol ISSN： 0014-4886 Impact factor: 5.330