Türker Acar1,2, Egemen Kaya3, Mustafa Deniz Yoruk4, Neslihan Duzenli5, Recep Selim Senturk5, Cenk Can5, Lokman Ozturk4, Canberk Tomruk6, Yigit Uyanikgil6, Frank J Rybicki7. 1. Department of Radiology, University of Health Sciences Bozyaka Education and Training Hospital, Saim Cikrici cd. No: 59 S.B.U. Bozyaka Egitim ve Arastirma Hastanesi Karabaglar, Izmir, Turkey. drtacar@hotmail.com. 2. Department of Radiology, University of Ottawa Faculty of Medicine and The Ottawa Hospital Research Institute, 451 Smyth Road, Ottawa, ON, Canada. drtacar@hotmail.com. 3. Department of Physiology, Ege University School of Medicine, Izmir, Turkey. 4. Department of Anatomy, Ege University School of Medicine, Izmir, Turkey. 5. Department of Pharmacology, Ege University School of Medicine, Izmir, Turkey. 6. Department of Histology, Ege University School of Medicine, Izmir, Turkey. 7. Department of Radiology, University of Ottawa Faculty of Medicine and The Ottawa Hospital Research Institute, 451 Smyth Road, Ottawa, ON, Canada.
Abstract
PURPOSE: This study investigated the potential to reduce gadolinium levels in rodents after repetitive IV Gadodiamide administration using several chelating agents. MATERIALS AND METHODS: The following six groups of rats were studied. Group 1: Control; Group 2: Gadodiamide only; Group 3: Meso-2,3-Dimercaptosuccinic acid (DMSA) + Gadodiamide; Group 4: N-Acetyl-L-cysteine (NAC) + Gadodiamide; Group 5: Coriandrum sativum extract + Gadodiamide; and Group 6: Deferoxamine + Gadodiamide. Brain, kidney, and blood samples were evaluated via inductively coupled plasma mass spectrometry. The brain was also evaluated histologically. RESULTS: Kidney gadolinium levels in Groups 4 and 5 were approximately double that of Group 2 (p = 0.033 for each). There was almost no calcification in rat hippocampus for Group 4 rodents when compared with Groups 2, 3, 5 and 6. CONCLUSION: Our preliminary study shows that excretion to the kidney has a higher propensity in NAC and Coriandrum sativum groups. It may be possible to change the distribution of gadolinium by administrating several agents. NAC may lower Gadodiamide-induced mineralization in rat hippocampus.
PURPOSE: This study investigated the potential to reduce gadolinium levels in rodents after repetitive IV Gadodiamide administration using several chelating agents. MATERIALS AND METHODS: The following six groups of rats were studied. Group 1: Control; Group 2: Gadodiamide only; Group 3: Meso-2,3-Dimercaptosuccinic acid (DMSA) + Gadodiamide; Group 4: N-Acetyl-L-cysteine (NAC) + Gadodiamide; Group 5: Coriandrum sativum extract + Gadodiamide; and Group 6: Deferoxamine + Gadodiamide. Brain, kidney, and blood samples were evaluated via inductively coupled plasma mass spectrometry. The brain was also evaluated histologically. RESULTS: Kidney gadolinium levels in Groups 4 and 5 were approximately double that of Group 2 (p = 0.033 for each). There was almost no calcification in rat hippocampus for Group 4 rodents when compared with Groups 2, 3, 5 and 6. CONCLUSION: Our preliminary study shows that excretion to the kidney has a higher propensity in NAC and Coriandrum sativum groups. It may be possible to change the distribution of gadolinium by administrating several agents. NAC may lower Gadodiamide-induced mineralization in rat hippocampus.
Authors: E A Wallnöfer; G C Thurner; C Kremser; H Talasz; M M Stollenwerk; A Helbok; N Klammsteiner; K Albrecht-Schgoer; H Dietrich; W Jaschke; P Debbage Journal: Histochem Cell Biol Date: 2020-10-11 Impact factor: 4.304