| Literature DB >> 30928708 |
Shahnaz Rostamizadeh1, Zahra Daneshfar2, Hamid Moghimi3.
Abstract
The present work describes the synthesis and spectroscopic characterization of ten different metal complexes of sulfabenzamide and sulfamethoxazole as ligands (M-SBZ, M-SMZ). Spectroscopic methods such as 1H NMR, UV-Vis spectroscopy analysis, FTIR and XRD confirmed the coordination of both ligands to metals through the nitrogen and oxygen atoms of the sulfonamide group. Both sulfabenzamide and sulfamethoxazole metal complexes were active against Gram-positive and negative bacterial strains. Sulfamethoxazole complexes showed their MIC values from 0.125 to 2.000 g ml-1 and sulfabenzamide complexes exhibited related MIC values from 1.000 to 2.000 g ml-1. Finally Zn (II) sulfamethoxazole with an inexpensive and common metal displayed more activity than its free ligand drug.Entities:
Keywords: Antibacterial agents; Metal; Sulfabenzamide; Sulfamethoxazole; Sulfonamide metal complex
Mesh：
Substances：
Year: 2019 PMID： 30928708 DOI： 10.1016/j.ejmech.2019.03.002
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514