Manuel Dote-Montero1, Francisco J Amaro-Gahete2, Alejandro De-la-O3, Lucas Jurado-Fasoli3, Angel Gutierrez3, Manuel J Castillo3. 1. Department of Medical Physiology, School of Medicine, University of Granada, 18016 Granada, Spain. Electronic address: manueldote@correo.ugr.es. 2. Department of Medical Physiology, School of Medicine, University of Granada, 18016 Granada, Spain. Electronic address: amarof@ugr.es. 3. Department of Medical Physiology, School of Medicine, University of Granada, 18016 Granada, Spain.
Abstract
BACKGROUND: α-Klotho is a recently discovered gene that accelerates ageing when disrupted and extends lifespan when overexpressed. The age-related decline in DHEAS and testosterone secretion and the increase in cortisol are associated with a rise of frailty and mortality. OBJECTIVE: To investigate the association of DHEAS, cortisol and testosterone plasma levels with S-Klotho plasma levels in healthy sedentary middle-aged adults. METHODS: 73 (39 women) healthy middle-aged sedentary adults (45-65 years old) were recruited for the present study. The blood samples were collected in the morning after fasting for 12 h. RESULTS: DHEAS was positively associated with S-Klotho in men (β = 0.521, R2 = 0.248, P = 0.002), whereas no association was observed in women (P ≥ 0.201). Testosterone was positively associated with S-Klotho in both men and women (β = 0.360, R2 = 0.099, P = 0.047; β = 0.431, R2 = 0.161, P = 0.010, respectively). No association was found between cortisol and S-Klotho neither in men nor in women (all P ≥ 0.141). The association between DHEAS and testosterone with S-Klotho in men disappeared after adjusting by age (all P ≥ 0.151). Nevertheless, the association between testosterone (β = 0.397, R2 = 0.423, P = 0.011) and S-Klotho in women remained after adjusting by age. CONCLUSIONS: DHEAS and testosterone were positively associated with S-Klotho in healthy sedentary middle-aged men while only testosterone was positively associated in women.
RCT Entities:
BACKGROUND: α-Klotho is a recently discovered gene that accelerates ageing when disrupted and extends lifespan when overexpressed. The age-related decline in DHEAS and testosterone secretion and the increase in cortisol are associated with a rise of frailty and mortality. OBJECTIVE: To investigate the association of DHEAS, cortisol and testosterone plasma levels with S-Klotho plasma levels in healthy sedentary middle-aged adults. METHODS: 73 (39 women) healthy middle-aged sedentary adults (45-65 years old) were recruited for the present study. The blood samples were collected in the morning after fasting for 12 h. RESULTS:DHEAS was positively associated with S-Klotho in men (β = 0.521, R2 = 0.248, P = 0.002), whereas no association was observed in women (P ≥ 0.201). Testosterone was positively associated with S-Klotho in both men and women (β = 0.360, R2 = 0.099, P = 0.047; β = 0.431, R2 = 0.161, P = 0.010, respectively). No association was found between cortisol and S-Klotho neither in men nor in women (all P ≥ 0.141). The association between DHEAS and testosterone with S-Klotho in men disappeared after adjusting by age (all P ≥ 0.151). Nevertheless, the association between testosterone (β = 0.397, R2 = 0.423, P = 0.011) and S-Klotho in women remained after adjusting by age. CONCLUSIONS:DHEAS and testosterone were positively associated with S-Klotho in healthy sedentary middle-aged men while only testosterone was positively associated in women.
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