Pei-Wei Tseng1, Jia-Sian Hou2, Du-An Wu3, Bang-Gee Hsu4. 1. School of Medicine, Tzu Chi University, Hualien, Taiwan. 2. Division of Nephrology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan. 3. School of Medicine, Tzu Chi University, Hualien, Taiwan; Division of Metabolism and Endocrinology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan. Electronic address: despdu@yahoo.com.tw. 4. School of Medicine, Tzu Chi University, Hualien, Taiwan; Division of Nephrology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan. Electronic address: gee.lily@msa.hinet.net.
Abstract
BACKGROUND: Adipocyte fatty acid binding protein (A-FABP) is a novel adipokine that contributes to the development of metabolic disorder, type 2 diabetes mellitus (T2DM) and atherosclerosis. We determined the correlation between serum A-FABP and aortic stiffness in T2DM patients. METHODS: Fasting blood samples were obtained from 156 patients with T2DM. Serum A-FABP concentration were determined using a commercial enzyme immunoassay. Carotid-femoral pulse wave velocity (cfPWV) was measured using SphygmoCor System, and cfPWV values of >10 m/s were defined as high aortic stiffness. RESULTS: Sixty participants (38.4%) fell under the high aortic stiffness group. This group, compared to the control group, showed older age (P = .004), higher systolic blood pressure (P < .001), diastolic blood pressure (P = .027), urine albumin-to-creatinine ratio (P = .003), serum A-FABP (P < .001) and lower estimated glomerular filtration rate (P = .001). After adjusting for factors significantly associated with aortic stiffness using multivariable logistic regression analysis, serum A-FABP [OR = 1.029 (1.002-1.058), P = .039] was found to be an independent predictor of aortic stiffness in T2DM patients. CONCLUSIONS: Serum A-FABP is positively correlated with aortic arterial stiffness in patients with T2DM.
BACKGROUND:Adipocyte fatty acid binding protein (A-FABP) is a novel adipokine that contributes to the development of metabolic disorder, type 2 diabetes mellitus (T2DM) and atherosclerosis. We determined the correlation between serum A-FABP and aortic stiffness in T2DM patients. METHODS: Fasting blood samples were obtained from 156 patients with T2DM. Serum A-FABP concentration were determined using a commercial enzyme immunoassay. Carotid-femoral pulse wave velocity (cfPWV) was measured using SphygmoCor System, and cfPWV values of >10 m/s were defined as high aortic stiffness. RESULTS: Sixty participants (38.4%) fell under the high aortic stiffness group. This group, compared to the control group, showed older age (P = .004), higher systolic blood pressure (P < .001), diastolic blood pressure (P = .027), urine albumin-to-creatinine ratio (P = .003), serum A-FABP (P < .001) and lower estimated glomerular filtration rate (P = .001). After adjusting for factors significantly associated with aortic stiffness using multivariable logistic regression analysis, serum A-FABP [OR = 1.029 (1.002-1.058), P = .039] was found to be an independent predictor of aortic stiffness in T2DM patients. CONCLUSIONS: Serum A-FABP is positively correlated with aortic arterial stiffness in patients with T2DM.
Authors: Boya Liao; Leiluo Geng; Fang Zhang; Lingling Shu; Ling Wei; Patrick K K Yeung; Karen S L Lam; Sookja K Chung; Junlei Chang; Paul M Vanhoutte; Aimin Xu; Kai Wang; Ruby L C Hoo Journal: Eur Heart J Date: 2020-09-01 Impact factor: 29.983