Literature DB >> 3092754

Effects of 17 beta-estradiol on the isolated rabbit heart.

R Raddino, C Manca, E Poli, R Bolognesi, O Visioli.   

Abstract

We have studied the effects of 17 beta-estradiol on the left ventricular pressure and on the coronary perfusion pressure in isolated rabbit heart, in order to evaluate the action of this hormone on the myocardial contractility and on the coronary resistances. 17 beta-Estradiol has induced a negative inotropic effect starting from a concentration of 10(-6) M and a vasodilation starting from 10(-7) M when administered on a vasopressin-induced coronary spasm. These effects are not related to sex or to alpha-, beta-adrenergic, histaminergic, anaesthetic-like mechanisms, but seem to interfere with calcium transport.

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Year:  1986        PMID： 3092754

Source DB:  PubMed          Journal:  Arch Int Pharmacodyn Ther        ISSN： 0003-9780


  13 in total

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2.  Investigation of the negative inotropic effects of 17 beta-oestradiol in human isolated myocardial tissues.

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3.  Antiarrhythmic effect and its underlying ionic mechanism of 17beta-estradiol in cardiac myocytes.

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5.  Effects of the novel calcium channel blocker, anipamil, on the isolated rabbit heart. Comparison with verapamil and gallopamil.

Authors:  R Raddino; E Poli; E Pasini; R Ferrari
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1992-09       Impact factor: 3.000

6.  The effect of 17beta-oestradiol on regional blood flow in anaesthetized pigs.

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Authors:  Richard E White; Ross Gerrity; Scott A Barman; Guichun Han
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8.  Effect of 17 beta-oestradiol on contraction, Ca2+ current and intracellular free Ca2+ in guinea-pig isolated cardiac myocytes.

Authors:  C Jiang; P A Poole-Wilson; P M Sarrel; S Mochizuki; P Collins; K T MacLeod
Journal:  Br J Pharmacol       Date:  1992-07       Impact factor: 8.739

9.  Regulation of beta adrenoceptor-mediated myocardial contraction and calcium dynamics by the G protein-coupled estrogen receptor 1.

Authors:  Victoria Whitcomb; Eric Wauson; Daniel Christian; Sarah Clayton; Jennifer Giles; Quang-Kim Tran
Journal:  Biochem Pharmacol       Date:  2019-11-21       Impact factor: 5.858

Review 10.  G-protein-coupled estrogen receptor as a new therapeutic target for treating coronary artery disease.

Authors:  Guichun Han; Richard E White
Journal:  World J Cardiol       Date:  2014-06-26
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