Hao Huang1, Hongying Kuang2, Fangbai Sun1, Michael P Diamond3, Richard S Legro4, Christos Coutifaris5, Ruben Alvero6, Randal D Robinson7, Peter R Casson8, Gregory M Christman9, Karl R Hansen10, Nanette Santoro6, Esther Eisenberg11, Heping Zhang12. 1. Department of Biostatistics, Yale University School of Public Health, New Haven, Connecticut. 2. Department of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, People's Republic of China. 3. Department of Obstetrics and Gynecology, Augusta University, Augusta, Georgia. 4. Department of Obstetrics and Gynecology, Pennsylvania State University, Hershey, Pennsylvania. 5. Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania. 6. Department of Obstetrics and Gynecology, University of Colorado, Denver, Colorado. 7. Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, San Antonio, Texas. 8. Department of Obstetrics and Gynecology, University of Vermont, Burlington, Vermont. 9. Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan. 10. University of Oklahoma College of Medicine, Oklahoma City, Oklahoma. 11. Fertility and Infertility Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, Maryland. 12. Department of Biostatistics, Yale University School of Public Health, New Haven, Connecticut. Electronic address: heping.zhang@yale.edu.
Abstract
OBJECTIVE: To study whether there is a difference in the prevalence of non-cavity-distorting uterine fibroids between infertile patients with polycystic ovary syndrome (PCOS) and those with unexplained infertility (UI). DESIGN: A secondary analysis of data from three randomized clinical trials. SETTING:Academic health centers. PATIENT(S): A total of 2,249 patients with normal uterine cavities. INTERVENTIONS(S): None. MAIN OUTCOME MEASURE(S): The presence or absence of non-cavity-distorting fibroids. RESULT(S): Compared with women with UI, those with PCOS were younger, had a higher body mass index, and were more likely to be Hispanic or African American, with a lower percentage of previous conception and live birth, a higher percentage of current smokers, a lower percentage of current alcohol users, and higher total testosterone, fasting insulin, and homeostasis-model-assessment insulin resistance. The prevalence of women with non-cavity-distorting uterine fibroids was lower in women with PCOS than in those with UI (6.7% vs. 12.4%); this result held after patients were divided into Black and non-Black or into three different body mass index groups. After adjustment for all the other variables in the final model, patients with PCOS had a significantly lower prevalence of fibroids than those with UI (odds ratio 0.54). No differences in the prevalence of non-cavity-distorting fibroids with any dimensions ≥4 cm or the volume of the largest fibroid was found between the two groups. CONCLUSION(S): A lower prevalence of non-cavity-distorting uterine fibroids was found in infertile women with PCOS than in those with UI.
RCT Entities:
OBJECTIVE: To study whether there is a difference in the prevalence of non-cavity-distorting uterine fibroids between infertilepatients with polycystic ovary syndrome (PCOS) and those with unexplained infertility (UI). DESIGN: A secondary analysis of data from three randomized clinical trials. SETTING: Academic health centers. PATIENT(S): A total of 2,249 patients with normal uterine cavities. INTERVENTIONS(S): None. MAIN OUTCOME MEASURE(S): The presence or absence of non-cavity-distorting fibroids. RESULT(S): Compared with women with UI, those with PCOS were younger, had a higher body mass index, and were more likely to be Hispanic or African American, with a lower percentage of previous conception and live birth, a higher percentage of current smokers, a lower percentage of current alcohol users, and higher total testosterone, fasting insulin, and homeostasis-model-assessment insulin resistance. The prevalence of women with non-cavity-distorting uterine fibroids was lower in women with PCOS than in those with UI (6.7% vs. 12.4%); this result held after patients were divided into Black and non-Black or into three different body mass index groups. After adjustment for all the other variables in the final model, patients with PCOS had a significantly lower prevalence of fibroids than those with UI (odds ratio 0.54). No differences in the prevalence of non-cavity-distorting fibroids with any dimensions ≥4 cm or the volume of the largest fibroid was found between the two groups. CONCLUSION(S): A lower prevalence of non-cavity-distorting uterine fibroids was found in infertilewomen with PCOS than in those with UI.
Authors: A E Taylor; B McCourt; K A Martin; E J Anderson; J M Adams; D Schoenfeld; J E Hall Journal: J Clin Endocrinol Metab Date: 1997-07 Impact factor: 5.958
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