Literature DB >> 30925301

Using stem cell-derived neurons in drug screening for neurological diseases.

Daniel Little1, Robin Ketteler2, Paul Gissen2, Michael J Devine3.   

Abstract

Induced pluripotent stem cells and their derivatives have become an important tool for researching disease mechanisms. It is hoped that they could be used to discover new therapies by providing the most reliable and relevant human in vitro disease models for drug discovery. This review will summarize recent efforts to use stem cell-derived neurons for drug screening. We also explain the current hurdles to using these cells for high-throughput pharmaceutical screening and developments that may help overcome these hurdles. Finally, we critically discuss whether induced pluripotent stem cell-derived neurons will come to fruition as a model that is regularly used to screen for drugs to treat neurological diseases.
Copyright © 2019 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Alzheimer's disease; Drug discovery; Drug screening; Embryonic stem cells; High content screening; Huntington's disease; Induced pluripotent stem cells; Motor neuron disease; Neurodegeneration; Parkinson's disease

Mesh：

Year:  2019        PMID： 30925301     DOI： 10.1016/j.neurobiolaging.2019.02.008

Source DB:  PubMed          Journal:  Neurobiol Aging        ISSN： 0197-4580            Impact factor:   4.673


  15 in total

1.  Botulinum neurotoxins A, B, C, E, and F preferentially enter cultured human motor neurons compared to other cultured human neuronal populations.

Authors:  Sabine Pellett; William H Tepp; Eric A Johnson
Journal:  FEBS Lett       Date:  2019-07-04       Impact factor: 4.124

2.  Electrophysiological- and Neuropharmacological-Based Benchmarking of Human Induced Pluripotent Stem Cell-Derived and Primary Rodent Neurons.

Authors:  Anna Jezierski; Ewa Baumann; Amy Aylsworth; Willard J Costain; Slavisa Corluka; Umberto Banderali; Caroline Sodja; Maria Ribecco-Lutkiewicz; Salma Alasmar; Marzia Martina; Joseph S Tauskela
Journal:  Stem Cell Rev Rep       Date:  2021-10-23       Impact factor: 5.739

Review 3.  Phenotyping Neurodegeneration in Human iPSCs.

Authors:  Jonathan Li; Ernest Fraenkel
Journal:  Annu Rev Biomed Data Sci       Date:  2021-04-23

4.  A multiparametric calcium signal screening platform using iPSC-derived cortical neural spheroids.

Authors:  Molly E Boutin; Caroline E Strong; Brittney Van Hese; Xin Hu; Zina Itkin; Yu-Chi Chen; Andrew LaCroix; Ryan Gordon; Oivin Guicherit; Cassiano Carromeu; Srikanya Kundu; Emily Lee; Marc Ferrer
Journal:  SLAS Discov       Date:  2022-01-31       Impact factor: 3.341

Review 5.  Human-Induced Pluripotent Stem Cell-Based Models for Studying Sex-Specific Differences in Neurodegenerative Diseases.

Authors:  Erkan Kiris
Journal:  Adv Exp Med Biol       Date:  2022       Impact factor: 3.650

Review 6.  Organoid and pluripotent stem cells in Parkinson's disease modeling: an expert view on their value to drug discovery.

Authors:  Nick Marotta; Soojin Kim; Dimitri Krainc
Journal:  Expert Opin Drug Discov       Date:  2020-01-03       Impact factor: 6.098

Review 7.  iPSCs: A Preclinical Drug Research Tool for Neurological Disorders.

Authors:  Gabriele Bonaventura; Rosario Iemmolo; Giuseppe Antonino Attaguile; Valentina La Cognata; Brigida Sabrina Pistone; Giuseppe Raudino; Velia D'Agata; Giuseppina Cantarella; Maria Luisa Barcellona; Sebastiano Cavallaro
Journal:  Int J Mol Sci       Date:  2021-04-27       Impact factor: 5.923

Review 8.  Glial Dysfunction and Its Contribution to the Pathogenesis of the Neuronal Ceroid Lipofuscinoses.

Authors:  Keigo Takahashi; Hemanth R Nelvagal; Jenny Lange; Jonathan D Cooper
Journal:  Front Neurol       Date:  2022-04-04       Impact factor: 4.086

Review 9.  Human in vitro models for understanding mechanisms of autism spectrum disorder.

Authors:  Aaron Gordon; Daniel H Geschwind
Journal:  Mol Autism       Date:  2020-04-16       Impact factor: 7.509

10.  A new patient-derived iPSC model for dystroglycanopathies validates a compound that increases glycosylation of α-dystroglycan.

Authors:  Jihee Kim; Beatrice Lana; Silvia Torelli; David Ryan; Francesco Catapano; Pierpaolo Ala; Christin Luft; Elizabeth Stevens; Evangelos Konstantinidis; Sandra Louzada; Beiyuan Fu; Amaia Paredes-Redondo; Aw Edith Chan; Fengtang Yang; Derek L Stemple; Pentao Liu; Robin Ketteler; David L Selwood; Francesco Muntoni; Yung-Yao Lin
Journal:  EMBO Rep       Date:  2019-09-30       Impact factor: 8.807
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