| Literature DB >> 30924422 |
Chao Yu1,2, Kaishun Xia1,2, Zhe Gong1,2, Liwei Ying1,2, Jiawei Shu1,2, Feng Zhang1,2, Qixin Chen1,2, Fangcai Li1,2, Chengzhen Liang1,2.
Abstract
Spinal cord injury (SCI) is a devastating event, and there are still no effective therapies currently available. Neural stem cells (NSCs) have gained increasing attention as promising regenerative therapy of SCI. NSCs based therapies of various neural diseases in animal models and clinical trials have been widely investigated. In this review we aim to summarize the development and recent progress in the application of NSCs in cell transplantation therapy for SCI. After brief introduction on sequential genetic steps regulating spinal cord development in vivo, we describe current experimental approaches for neural induction of NSCs in vitro. In particular, we focus on NSCs induced from pluripotent stem cells (PSCs). Finally, we highlight recent progress on the NSCs, which show great promise in the application to regeneration therapy for SCI. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Entities:
Keywords: Spinal cord injury; macrophages; neural induction; neural stem cell; patient; pluripotent stem cell.
Year: 2019 PMID： 30924422 DOI： 10.2174/1574888X14666190329095638
Source DB: PubMed Journal: Curr Stem Cell Res Ther ISSN： 1574-888X Impact factor: 3.828