Jay Portnoy1, Rolin L Wade2, Catherine Kessler3. 1. Children's Mercy Hospitals & Clinics, Kansas City, Mo. Electronic address: jportnoy@cmh.edu. 2. IQVIA Inc (formerly Quintiles IMS Holdings), Plymouth Meeting, Pa. 3. kaleo, Inc, Richmond, Va.
Abstract
BACKGROUND: Limited real-world data exist regarding patient carrying compliance and confidence in using different types of epinephrine autoinjectors (EAIs). OBJECTIVE: To perform a Real-world Assessment of Patients' Carrying Time and Confidence with Epinephrine Autoinjector Devices (RACE survey). METHODS: This was a noninterventional survey of patients (≥7 years) who filled 1 or more prescription for Auvi-Q or EpiPen between January 2013 and January 2014. Outcomes included proportion of patients carrying their EAI all the time in the last 7 days (primary), EAI use confidence (secondary), and EAI training experience (secondary). Multivariate regression analyses controlled for significant differences in demographic and clinical characteristics between EAI groups. RESULTS: The survey included 2,000 participants (Auvi-Q, N = 1,000 [children, n = 597; adults, n = 403]; EpiPen, N = 1,000 [children, n = 105; adults, n = 895]). After adjusting for confounding factors, we found that Auvi-Q respondents were more likely to carry their device all the time in the last 7 days versus EpiPen respondents (adjusted odds ratio [aOR], 1.91; 95% CI, 1.49-2.45; P < .001); similar trends were observed in adults and children (P < .001 both). Adults in the Auvi-Q group were more likely to feel "very confident" about correctly using their EAI (aOR, 2.02) and someone else correctly using their EAI (aOR, 2.25) versus the EpiPen group (P < .001 both). Compared with EpiPen respondents, Auvi-Q respondents were more likely to feel that EAI instructions were "very clear" (aOR, 3.10) and more likely to find the prescription pack trainer helpful (aOR, 2.29; P < .01 both). CONCLUSIONS: This study suggests significant real-world differences in patients' carrying time, confidence in use, and training experiences between Auvi-Q and EpiPen users.
BACKGROUND: Limited real-world data exist regarding patient carrying compliance and confidence in using different types of epinephrine autoinjectors (EAIs). OBJECTIVE: To perform a Real-world Assessment of Patients' Carrying Time and Confidence with Epinephrine Autoinjector Devices (RACE survey). METHODS: This was a noninterventional survey of patients (≥7 years) who filled 1 or more prescription for Auvi-Q or EpiPen between January 2013 and January 2014. Outcomes included proportion of patients carrying their EAI all the time in the last 7 days (primary), EAI use confidence (secondary), and EAI training experience (secondary). Multivariate regression analyses controlled for significant differences in demographic and clinical characteristics between EAI groups. RESULTS: The survey included 2,000 participants (Auvi-Q, N = 1,000 [children, n = 597; adults, n = 403]; EpiPen, N = 1,000 [children, n = 105; adults, n = 895]). After adjusting for confounding factors, we found that Auvi-Q respondents were more likely to carry their device all the time in the last 7 days versus EpiPen respondents (adjusted odds ratio [aOR], 1.91; 95% CI, 1.49-2.45; P < .001); similar trends were observed in adults and children (P < .001 both). Adults in the Auvi-Q group were more likely to feel "very confident" about correctly using their EAI (aOR, 2.02) and someone else correctly using their EAI (aOR, 2.25) versus the EpiPen group (P < .001 both). Compared with EpiPen respondents, Auvi-Q respondents were more likely to feel that EAI instructions were "very clear" (aOR, 3.10) and more likely to find the prescription pack trainer helpful (aOR, 2.29; P < .01 both). CONCLUSIONS: This study suggests significant real-world differences in patients' carrying time, confidence in use, and training experiences between Auvi-Q and EpiPen users.
Authors: Kenneth L Dretchen; Zack Mesa; Matthew Robben; Desmond Slade; Scott Hill; Claire Croutch; Kyle Kappeler; Michael Mesa Journal: Pharmacol Res Perspect Date: 2020-04