| Literature DB >> 30922976 |
Ghulam Murtaza1, Hafeez Ul Hassan Virk2, Muhammad Khalid1, Carl J Lavie3, Hector Ventura3, Debabrata Mukherjee4, Vijay Ramu1, Sukhdeep Bhogal1, Gautam Kumar5, Madhan Shanmugasundaram6, Timir K Paul7.
Abstract
Diabetes causes cardiomyopathy and increases the risk of heart failure independent of hypertension and coronary heart disease. This condition called "Diabetic Cardiomyopathy" (DCM) is becoming a well- known clinical entity. Recently, there has been substantial research exploring its molecular mechanisms, structural and functional changes, and possible development of therapeutic approaches for the prevention and treatment of DCM. This review summarizes the recent advancements to better understand fundamental molecular abnormalities that promote this cardiomyopathy and novel therapies for future research. Additionally, different diagnostic modalities, up to date screening tests to guide clinicians with early diagnosis and available current treatment options has been outlined.Entities:
Keywords: Cardiomyopathy; Diabetes; Diastolic dysfunction; Ejection fraction; Heart failure; Risk factors
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Year: 2019 PMID： 30922976 DOI： 10.1016/j.pcad.2019.03.003
Source DB: PubMed Journal: Prog Cardiovasc Dis ISSN： 0033-0620 Impact factor: 8.194