Literature DB >> 30922524

STIM1 holds a STING in its (N-terminal) tail.

Aran Son1, Adriana Almeida de Jesus2, Daniella M Schwartz3.   

Abstract

The Ca2+ sensor STIM1 is essential for adaptive immune responses, yet patients with hypomorphic STIM1 mutations develop both immunodeficiency and autoimmunity, implying that STIM1 also restrains immune responses. This study by Srikanth et al demonstrates that STIM1 tethers STING, a major inducer of the interferon (IFN) response, to the endoplasmic reticulum (ER) to prevent constitutive STING activation. Published by Elsevier Ltd.

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Year:  2019        PMID： 30922524      PMCID： PMC6686850          DOI： 10.1016/j.ceca.2019.03.003

Source DB:  PubMed          Journal:  Cell Calcium        ISSN： 0143-4160            Impact factor:   6.817


  7 in total

1.  Cutting Edge: Activation of STING in T Cells Induces Type I IFN Responses and Cell Death.

Authors:  Bridget Larkin; Vladimir Ilyukha; Maxim Sorokin; Anton Buzdin; Edouard Vannier; Alexander Poltorak
Journal:  J Immunol       Date:  2017-06-14       Impact factor: 5.422

2.  Activated STING in a vascular and pulmonary syndrome.

Authors:  Y Liu; A A Jesus; B Marrero; Z Deng; M Boehm; A S Paller; D Yang; S E Ramsey; G A Montealegre Sanchez; K Tenbrock; H Wittkowski; O Y Jones; H S Kuehn; C-C R Lee; M A DiMattia; E W Cowen; B Gonzalez; I Palmer; J J DiGiovanna; A Biancotto; H Kim; W L Tsai; A M Trier; Y Huang; D L Stone; S Hill; H J Kim; C St Hilaire; S Gurprasad; N Plass; D Chapelle; I Horkayne-Szakaly; D Foell; A Barysenka; F Candotti; S M Holland; J D Hughes; H Mehmet; A C Issekutz; M Raffeld; J McElwee; J R Fontana; C P Minniti; S Moir; D L Kastner; M Gadina; A C Steven; P T Wingfield; S R Brooks; S D Rosenzweig; T A Fleisher; R Goldbach-Mansky
Journal:  N Engl J Med       Date:  2014-07-16       Impact factor: 91.245

3.  Endoplasmic reticulum stress regulates the innate immunity critical transcription factor IRF3.

Authors:  Yi-Ping Liu; Ling Zeng; Austin Tian; Ashley Bomkamp; Daniel Rivera; Delia Gutman; Glen N Barber; Julie K Olson; Judith A Smith
Journal:  J Immunol       Date:  2012-10-01       Impact factor: 5.422

4.  STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway.

Authors:  Yasuo Tanaka; Zhijian J Chen
Journal:  Sci Signal       Date:  2012-03-06       Impact factor: 8.192

Review 5.  Orai1 and STIM1 in ER/PM junctions: roles in pancreatic cell function and dysfunction.

Authors:  Aran Son; Seonghee Park; Dong Min Shin; Shmuel Muallem
Journal:  Am J Physiol Cell Physiol       Date:  2016-01-06       Impact factor: 4.249

Review 6.  Ion channelopathies of the immune system.

Authors:  Martin Vaeth; Stefan Feske
Journal:  Curr Opin Immunol       Date:  2018-04-07       Impact factor: 7.486

7.  The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum.

Authors:  Sonal Srikanth; Jin Seok Woo; Beibei Wu; Yasser M El-Sherbiny; Jennifer Leung; Koollawat Chupradit; Laura Rice; Gil Ju Seo; Guillaume Calmettes; Chandran Ramakrishna; Edouard Cantin; Dong Sung An; Ren Sun; Ting-Ting Wu; Jae U Jung; Sinisa Savic; Yousang Gwack
Journal:  Nat Immunol       Date:  2019-01-14       Impact factor: 25.606
  7 in total
  1 in total

Review 1.  Common innate pathways to autoimmune disease.

Authors:  David Langan; Noel R Rose; Kamal D Moudgil
Journal:  Clin Immunol       Date:  2020-02-10       Impact factor: 3.969
  1 in total

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