Zhanwu Yu1, Yu Liu1, Ying Cui2, Rui Ma1, Huan Zhan3, Wendong Chen3,4, Hongxu Liu1. 1. Department of Thoracic Surgery, Liaoning Cancer Hospital & Institute, China Medical University, Shenyang, China 110042. 2. Department of Medical Reimbursement, Liaoning Cancer Hospital & Institute, China Medical University, Shenyang, China 110042. 3. Changsha Normin Health Technology Ltd, Changsha, China 410013. 4. Normin Health Consulting Ltd, Toronto, Canada L5R 0E9.
Abstract
Aim: To assess the cost-effectiveness of standard utilization of zoledronic acid (ZA) relative to real-world utilization of ZA for bone metastasis (BM) in Chinese patients with advanced lung cancer. Materials & methods: A decision analytic model was constructed to simulate health benefits and medical costs associated with standard and real-world utilization of ZA for BM in Chinese patients with advanced lung cancer. Results: Compared with real-world utilization of ZA, standard utilization of ZA reduced cumulative risk of skeletal-related events (45.7 vs 63.6%), increased quality-adjusted life years (0.673 vs 0.626 QALY) and saved cumulated medical costs (¥343,163 vs ¥376,943). Conclusion: Standard utilization of ZA dominated real-world utilization of ZA for BM in Chinese patients with advanced lung cancer from cost-effectiveness perspective.
Aim: To assess the cost-effectiveness of standard utilization of zoledronic acid (ZA) relative to real-world utilization of ZA for bone metastasis (BM) in Chinese patients with advanced lung cancer. Materials & methods: A decision analytic model was constructed to simulate health benefits and medical costs associated with standard and real-world utilization of ZA for BM in Chinese patients with advanced lung cancer. Results: Compared with real-world utilization of ZA, standard utilization of ZA reduced cumulative risk of skeletal-related events (45.7 vs 63.6%), increased quality-adjusted life years (0.673 vs 0.626 QALY) and saved cumulated medical costs (¥343,163 vs ¥376,943). Conclusion: Standard utilization of ZA dominated real-world utilization of ZA for BM in Chinese patients with advanced lung cancer from cost-effectiveness perspective.
Entities:
Keywords:
bone metastasis; cost–effectiveness; lung cancer; skeletal-related events; zoledronic acid