Boris Cheval1,2, Clovis Chabert3, Stefan Sieber4, Dan Orsholits4, Rachel Cooper5, Idris Guessous6, David Blane7, Matthias Kliegel4,8, Delphine S Courvoisier4,9, Michelle Kelly-Irving10,11, Matthieu P Boisgontier12,13, Stéphane Cullati4,9. 1. Swiss NCCR "LIVES - Overcoming Vulnerability: Life Course Perspectives," University of Geneva, Geneva, Switzerland, boris.cheval@unige.ch. 2. Department of General Internal Medicine, Rehabilitation, and Geriatrics, University of Geneva, Geneva, Switzerland, boris.cheval@unige.ch. 3. Laboratory ACTES (EA 3596), French West Indies University, Pointe-à-Pitre, France. 4. Swiss NCCR "LIVES - Overcoming Vulnerability: Life Course Perspectives," University of Geneva, Geneva, Switzerland. 5. MRC Unit for Lifelong Health and Ageing at UCL, London, United Kingdom. 6. Unit of Population Epidemiology, Department of Community Medicine, Primary Care, and Emergency Medicine, Geneva University Hospitals, Geneva, Switzerland. 7. Department of Epidemiology and Public Health, International Centre for Life Course Studies in Society and Health, University College London, London, United Kingdom. 8. Center for the Interdisciplinary Study of Gerontology and Vulnerability, University of Geneva, Geneva, Switzerland. 9. Department of General Internal Medicine, Rehabilitation, and Geriatrics, University of Geneva, Geneva, Switzerland. 10. INSERM, UMR1027, Toulouse, France. 11. Université Toulouse III Paul Sabatier, UMR1027, Toulouse, France. 12. Movement Control and Neuroplasticity Research Group, Department of Movement Sciences, KU Leuven, Leuven, Belgium. 13. Brain Behavior Laboratory, Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada.
Abstract
BACKGROUND: Muscle weakness - a biomarker of health - may have its origins in early life and be related to factors such as adverse childhood experiences (ACE), which refer to a set of early-life traumatic and stressful psychosocial events out of the child's control. To date, evidence of an association between ACE and muscle strength in older age is lacking. -Objective: Here, we assessed the associations between ACE during the first 15 years of life and the risk of low muscle strength (LMS) later in life. We also examined whether adult-life socioeconomic circumstances (i.e., educational attainment, main occupational position, and satisfaction with household financial situation) and unhealthy behaviors (i.e., physical inactivity, unhealthy eating, smoking, and high level of alcohol consumption) explained this association. METHODS: We used data from the Survey of Health, Ageing, and Retirement in Europe, a 12-year cohort study with 6 -repeated measurements between 2004 and 2015. Muscle strength was measured using a handheld dynamometer. Confounder-adjusted logistic mixed-effect models were used to examine the associations between ACE (child in care, parental death, parental mental illness, parental drinking, period of hunger, or property taken away) and the risk of LMS in older age. - Results: 24,179 participants (96,372 observations; 13,477 women; aged 50-96 years) living in 14 countries were included. LMS increased with age for both genders. For women, there was a gradual increase in the risk of LMS with the number of experienced ACE (ORs = 1.22 for 1 ACE, 1.74 for ≥2 ACE compared to no ACE). However, there was no significant association among men. This association was only slightly attenuated when adjusting for socioeconomic circumstances and unhealthy behaviors in adulthood. CONCLUSIONS: ACE are associated with later-life muscle weakness among women. These associations were not compensated by the adoption of healthy behaviors or an improvement in socioeconomic circumstances in adulthood. These results suggest that tackling these early-life risk factors in women could promote long-term grip strength, a biomarker of aging.
BACKGROUND:Muscle weakness - a biomarker of health - may have its origins in early life and be related to factors such as adverse childhood experiences (ACE), which refer to a set of early-life traumatic and stressful psychosocial events out of the child's control. To date, evidence of an association between ACE and muscle strength in older age is lacking. -Objective: Here, we assessed the associations between ACE during the first 15 years of life and the risk of low muscle strength (LMS) later in life. We also examined whether adult-life socioeconomic circumstances (i.e., educational attainment, main occupational position, and satisfaction with household financial situation) and unhealthy behaviors (i.e., physical inactivity, unhealthy eating, smoking, and high level of alcohol consumption) explained this association. METHODS: We used data from the Survey of Health, Ageing, and Retirement in Europe, a 12-year cohort study with 6 -repeated measurements between 2004 and 2015. Muscle strength was measured using a handheld dynamometer. Confounder-adjusted logistic mixed-effect models were used to examine the associations between ACE (child in care, parental death, parental mental illness, parental drinking, period of hunger, or property taken away) and the risk of LMS in older age. - Results: 24,179 participants (96,372 observations; 13,477 women; aged 50-96 years) living in 14 countries were included. LMS increased with age for both genders. For women, there was a gradual increase in the risk of LMS with the number of experienced ACE (ORs = 1.22 for 1 ACE, 1.74 for ≥2 ACE compared to no ACE). However, there was no significant association among men. This association was only slightly attenuated when adjusting for socioeconomic circumstances and unhealthy behaviors in adulthood. CONCLUSIONS: ACE are associated with later-life muscle weakness among women. These associations were not compensated by the adoption of healthy behaviors or an improvement in socioeconomic circumstances in adulthood. These results suggest that tackling these early-life risk factors in women could promote long-term grip strength, a biomarker of aging.
Authors: Boris Cheval; Matthieu P Boisgontier; Stefan Sieber; Andreas Ihle; Dan Orsholits; Cyril Forestier; David Sander; Aïna Chalabaev Journal: Eur J Ageing Date: 2021-10-01
Authors: Boris Cheval; Silvio Maltagliati; Stefan Sieber; David Beran; Aïna Chalabaev; David Sander; Stéphane Cullati; Matthieu P Boisgontier Journal: Ann Behav Med Date: 2021-08-23
Authors: Aïna Chalabaev; Stefan Sieber; David Sander; Stéphane Cullati; Silvio Maltagliati; Philippe Sarrazin; Matthieu P Boisgontier; Boris Cheval Journal: Psychol Sci Date: 2022-02-03
Authors: Bernadette Wilhelmina Antonia Van Der Linden; Stefan Sieber; Boris Cheval; Dan Orsholits; Idris Guessous; Rainer Gabriel; Martina Von Arx; Michelle Kelly-Irving; Marja Aartsen; David Blane; Matthieu P Boisgontier; Delphine Courvoisier; Michel Oris; Matthias Kliegel; Stéphane Cullati Journal: J Gerontol B Psychol Sci Soc Sci Date: 2020-06-02 Impact factor: 4.077