Literature DB >> 30920803

Red Fluorescence Probe Targeted to Dipeptidylpeptidase-IV for Highly Sensitive Detection of Esophageal Cancer.

Akira Ogasawara, Mako Kamiya1, Kei Sakamoto, Yugo Kuriki, Kyohhei Fujita, Toru Komatsu, Tasuku Ueno, Kenjiro Hanaoka, Haruna Onoyama, Hiroyuki Abe, Yosuke Tsuji, Mitsuhiro Fujishiro2, Kazuhiko Koike, Masashi Fukayama, Yasuyuki Seto, Yasuteru Urano3.   

Abstract

We have developed an activatable red fluorescence probe for dipeptidylpeptidase-IV (DPP-IV) by precisely controlling the photoinduced electron transfer (PeT) process of a red fluorescent scaffold, SiR600. The developed probe exhibited an extremely low background signal and showed significant fluorescence activation upon reaction with DPP-IV, enabling sensitive detection of esophageal cancer in clinical specimens from cancer patients.

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Year:  2019        PMID： 30920803     DOI： 10.1021/acs.bioconjchem.9b00198

Source DB:  PubMed          Journal:  Bioconjug Chem        ISSN： 1043-1802            Impact factor:   4.774


  5 in total

1.  Rapid and Sensitive Detection of Cancer Cells with Activatable Fluorescent Probes for Enzyme Activity.

Authors:  Kyohhei Fujita; Mako Kamiya; Yasuteru Urano
Journal:  Methods Mol Biol       Date:  2021

2.  Molecular design of near-infrared (NIR) fluorescent probes targeting exopeptidase and application for detection of dipeptidyl peptidase 4 (DPP-4) activity.

Authors:  Yuki Hoshino; Kenjiro Hanaoka; Kei Sakamoto; Masahiro Yasunaga; Takashi Kojima; Daisuke Kotani; Ayumu Nomoto; Eita Sasaki; Toru Komatsu; Tasuku Ueno; Hiroyuki Takamaru; Yutaka Saito; Yasuyuki Seto; Yasuteru Urano
Journal:  RSC Chem Biol       Date:  2022-03-24

Review 3.  Optical substrates for drug-metabolizing enzymes: Recent advances and future perspectives.

Authors:  Qiang Jin; JingJing Wu; Yue Wu; Hongxin Li; Moshe Finel; Dandan Wang; Guangbo Ge
Journal:  Acta Pharm Sin B       Date:  2022-01-21       Impact factor: 14.903

4.  Development of a fluorescent probe library enabling efficient screening of tumour-imaging probes based on discovery of biomarker enzymatic activities.

Authors:  Yugo Kuriki; Takafusa Yoshioka; Mako Kamiya; Toru Komatsu; Hiroyuki Takamaru; Kyohhei Fujita; Hirohisa Iwaki; Aika Nanjo; Yuki Akagi; Kohei Takeshita; Haruaki Hino; Rumi Hino; Ryosuke Kojima; Tasuku Ueno; Kenjiro Hanaoka; Seiichiro Abe; Yutaka Saito; Jun Nakajima; Yasuteru Urano
Journal:  Chem Sci       Date:  2022-03-21       Impact factor: 9.969

5.  Rapid imaging of lung cancer using a red fluorescent probe to detect dipeptidyl peptidase 4 and puromycin-sensitive aminopeptidase activities.

Authors:  Shun Kawashima; Daisuke Yoshida; Takafusa Yoshioka; Akira Ogasawara; Kyohhei Fujita; Masahiro Yanagiya; Masaaki Nagano; Chihiro Konoeda; Haruaki Hino; Kentaro Kitano; Masaaki Sato; Rumi Hino; Ryosuke Kojima; Toru Komatsu; Mako Kamiya; Yasuteru Urano; Jun Nakajima
Journal:  Sci Rep       Date:  2022-06-01       Impact factor: 4.996
  5 in total

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