Sung-Wan Kim1, Jung Jin Kim2, Bong Ju Lee3, Je-Chun Yu4, Kyu Young Lee5, Seung-Hee Won6, Seung-Hwan Lee7, Seung-Hyun Kim8, Shi-Hyun Kang9, Euitae Kim10, Ju-Yeon Lee1, Jae-Min Kim1, Young Chul Chung11. 1. Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea. 2. Department of Psychiatry, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Korea. 3. Department of Psychiatry, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea. 4. Department of Psychiatry, Eulji University School of Medicine, Eulji University Hospital, Daejeon, Korea. 5. Department of Psychiatry, Eulji University School of Medicine, Eulji General Hospital, Seoul, Korea. 6. Department of Psychiatry, Kyungpook National University School of Medicine, Daegu, Korea. 7. Department of Psychiatry, Inje University College of Medicine, Goyang, Korea. 8. Department of Psychiatry, Korea University College of Medicine, Guro Hospital, Seoul, Korea. 9. Department of Psychiatry, Seoul National Hospital, Seoul, Korea. 10. Department of Neuropsychiatry, Seoul National University Bundang Hospital, Gyeonggi-do, Korea. 11. Department of Psychiatry, Chonbuk National University Medical School, Jeonju, Republic of Korea.
Abstract
AIM: This study investigated the clinical characteristics and psychosocial factors associated with depression in patients with early psychosis according to stage of illness. METHODS: The present study includes patients who fulfil the DSM-5 criteria for schizophrenia spectrum and other psychotic disorders. Patients were divided into two groups according to illness stage (the acute stage of first-episode psychosis and stabilization phase of recent-onset psychosis). Clinically meaningful depression was defined as moderate or severe on the depression dimension of the Clinician-Rated Dimensions of Psychosis Symptom Severity scale in the DSM-5. RESULTS: In total, 340 (207 first-episode and 133 recent-onset) patients were recruited in this study. Patients with comorbid depression were characterized by frequent suicidal ideation, a past suicide attempt, and lower scores on the Subjective Well-being Under Neuroleptics and Brief Resilience Scale in both groups. Long duration of untreated psychosis and higher scores on the Early Trauma Inventory Self Report were associated with depression in the acute stage of first-episode psychosis. In the stabilization phase of recent-onset psychosis group, a monthly income and scores for sexual desire and on the Family Adaptability and Cohesion Evaluation Scale-III were significantly lower in patients with depression than in those without depression. CONCLUSION: Comorbid depression was associated with high suicidality, lower quality of life and poor resilience in patients with first-episode and recent-onset psychosis. Depression was associated with factors that had been present before the initiation of treatment in patients with first-episode psychosis and with environmental factors in those in the stabilization phase.
AIM: This study investigated the clinical characteristics and psychosocial factors associated with depression in patients with early psychosis according to stage of illness. METHODS: The present study includes patients who fulfil the DSM-5 criteria for schizophrenia spectrum and other psychotic disorders. Patients were divided into two groups according to illness stage (the acute stage of first-episode psychosis and stabilization phase of recent-onset psychosis). Clinically meaningful depression was defined as moderate or severe on the depression dimension of the Clinician-Rated Dimensions of Psychosis Symptom Severity scale in the DSM-5. RESULTS: In total, 340 (207 first-episode and 133 recent-onset) patients were recruited in this study. Patients with comorbid depression were characterized by frequent suicidal ideation, a past suicide attempt, and lower scores on the Subjective Well-being Under Neuroleptics and Brief Resilience Scale in both groups. Long duration of untreated psychosis and higher scores on the Early Trauma Inventory Self Report were associated with depression in the acute stage of first-episode psychosis. In the stabilization phase of recent-onset psychosis group, a monthly income and scores for sexual desire and on the Family Adaptability and Cohesion Evaluation Scale-III were significantly lower in patients with depression than in those without depression. CONCLUSION: Comorbid depression was associated with high suicidality, lower quality of life and poor resilience in patients with first-episode and recent-onset psychosis. Depression was associated with factors that had been present before the initiation of treatment in patients with first-episode psychosis and with environmental factors in those in the stabilization phase.