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Literature DB >> 30919341

PFKP Signaling at a Glance: An Emerging Mediator of Cancer Cell Metabolism.

Liwei Lang¹, Ron Chemmalakuzhy², Chloe Shay^3,4, Yong Teng^5,6,7.

Abstract

Phosphofructokinase-1 (PFK-1), a rate-determining enzyme of glycolysis, is an allosteric enzyme that regulates the oxidation of glucose in cellular respiration. Glycolysis phosphofructokinase platelet (PFKP) is the platelet isoform and works as an important mediator of cell metabolism. Considering that PFKP is a crucial player in many steps of cancer initiation and metastasis, we reviewed the specificities and complexities of PFKP and its biological roles in human diseases, especially malignant tumors. The possible use of PFKP as a diagnostic marker or a drug target in the prevention or treatment of cancer is also discussed.

Entities: Chemical Disease Gene Species

Keywords: Biologic roles; Cancer; Diagnostic marker; Drug target; Gene regulations; PFKP

Mesh：

Substances：

Year: 2019 PMID： 30919341 DOI： 10.1007/978-3-030-12668-1_13

Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622

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Cited

12 in total

1. Astragalus polysaccharide mitigates transport stress-induced hepatic metabolic stress via improving hepatic glucolipid metabolism in chicks.

Authors: Bi-Chen Zhao; Yi-Xi Tang; Bai-Hao Qiu; Hao-Liang Xu; Tian-Hao Wang; Ahmed Ibrahim Ahmed Elsherbeni; Hassan Bayoumi Ali Gharib; Jin-Long Li
Journal: J Anim Sci Date: 2022-09-01 Impact factor: 3.338

2. Identification of DNA methylation patterns and biomarkers for clear-cell renal cell carcinoma by multi-omics data analysis.

Authors: Pengfei Liu; Weidong Tian
Journal: PeerJ Date: 2020-08-03 Impact factor: 2.984

3. Targeting Glycolysis with Epigallocatechin-3-Gallate Enhances the Efficacy of Chemotherapeutics in Pancreatic Cancer Cells and Xenografts.

Authors: Ran Wei; Robert M Hackman; Yuefei Wang; Gerardo G Mackenzie
Journal: Cancers (Basel) Date: 2019-10-05 Impact factor: 6.639

4. Interplay Between Glucose Metabolism and Chromatin Modifications in Cancer.

Authors: Rui Ma; Yinsheng Wu; Shanshan Li; Xilan Yu
Journal: Front Cell Dev Biol Date: 2021-04-27

5. Bacillus toyonensis SAU-19 Ameliorates Hepatic Insulin Resistance in High-Fat Diet/Streptozocin-Induced Diabetic Mice.

Authors: Samuel Kumi Okyere; Lei Xie; Juan Wen; Yinan Ran; Zhihua Ren; Junliang Deng; Yanchun Hu
Journal: Nutrients Date: 2021-12-17 Impact factor: 5.717

PFKP Signaling at a Glance: An Emerging Mediator of Cancer Cell Metabolism.

1. Astragalus polysaccharide mitigates transport stress-induced hepatic metabolic stress via improving hepatic glucolipid metabolism in chicks.

2. Identification of DNA methylation patterns and biomarkers for clear-cell renal cell carcinoma by multi-omics data analysis.

3. Targeting Glycolysis with Epigallocatechin-3-Gallate Enhances the Efficacy of Chemotherapeutics in Pancreatic Cancer Cells and Xenografts.

4. Interplay Between Glucose Metabolism and Chromatin Modifications in Cancer.

5. Bacillus toyonensis SAU-19 Ameliorates Hepatic Insulin Resistance in High-Fat Diet/Streptozocin-Induced Diabetic Mice.

6. PFKP Activation Ameliorates Foot Process Fusion in Podocytes in Diabetic Kidney Disease.

7. Blockade of glutamine-dependent cell survival augments antitumor efficacy of CPI-613 in head and neck cancer.

8. Establishment and Analysis of Hypoxia-Related Model in Oral Squamous Cell Carcinoma.

Review 9. Targeting Hypoxia-Driven Metabolic Reprogramming to Constrain Tumor Progression and Metastasis.

Review 10. Choosing Kinase Inhibitors for Androgen Deprivation Therapy-Resistant Prostate Cancer.