Xiaohui Zhao1, Drishti Shah1, Usha Sambamoorthi1. 1. Department of Pharmaceutical Systems and Policy, School of Pharmacy, West Virginia University, 1 Medical Center Drive, PO Box 9510, Morgantown, WV 26506 USA.
Abstract
PURPOSE: The association between chronic hepatitis B (CHB) infection and metabolic syndrome (MetS) remains inconclusive. This study was designed to determine the association between CHB infection and MetS among the US population with updated data and adjustments for a comprehensive set of risk factors. METHODS: Adults aged 18 years or older who were clinically assessed for Hepatitis B and MetS from the National Health and Nutrition Examination Survey (NHANES) 2003-2004, 2005-2006, 2007-2008, 2009-2010, 2011-2012, and 2013-2014 cycles were included in the study (N = 53,392,666). MetS was defined according to the NCEP/ATP III guideline. CHB was identified by the seropositivity of Hepatitis B surface antigen and core antibody in the absence of Hepatitis B surface antibody. Rao-Scott χ 2test and logistic regressions were employed in the analyses. RESULTS: MetS was less prevalent among adults with CHB compared to adults without CHB (12.1% vs. 18.8%, p = 0.073). In adjusted analyses, adults with CHB were 48% less likely to have MetS compared to those without CHB (95% Confidence Interval [CI]: 0.29-0.94). Regarding individual component of MetS, CHB was inversely associated with high waist circumference (AOR = 0.32, 95% CI: 0.21-0.49) and hypoalphalipoproteinemia (AOR = 0.48, 95% CI: 0.25-0.91). No association between CHB and other metabolic components were found. CONCLUSIONS: CHB was inversely associated with MetS, high waist circumference, and hypoalphalipoproteinemia. No significant association was found between CHB and other MetS components.
PURPOSE: The association between chronic hepatitis B (CHB) infection and metabolic syndrome (MetS) remains inconclusive. This study was designed to determine the association between CHB infection and MetS among the US population with updated data and adjustments for a comprehensive set of risk factors. METHODS: Adults aged 18 years or older who were clinically assessed for Hepatitis B and MetS from the National Health and Nutrition Examination Survey (NHANES) 2003-2004, 2005-2006, 2007-2008, 2009-2010, 2011-2012, and 2013-2014 cycles were included in the study (N = 53,392,666). MetS was defined according to the NCEP/ATP III guideline. CHB was identified by the seropositivity of Hepatitis B surface antigen and core antibody in the absence of Hepatitis B surface antibody. Rao-Scott χ 2test and logistic regressions were employed in the analyses. RESULTS: MetS was less prevalent among adults with CHB compared to adults without CHB (12.1% vs. 18.8%, p = 0.073). In adjusted analyses, adults with CHB were 48% less likely to have MetS compared to those without CHB (95% Confidence Interval [CI]: 0.29-0.94). Regarding individual component of MetS, CHB was inversely associated with high waist circumference (AOR = 0.32, 95% CI: 0.21-0.49) and hypoalphalipoproteinemia (AOR = 0.48, 95% CI: 0.25-0.91). No association between CHB and other metabolic components were found. CONCLUSIONS: CHB was inversely associated with MetS, high waist circumference, and hypoalphalipoproteinemia. No significant association was found between CHB and other MetS components.
Entities:
Keywords:
Chronic hepatitis B infection; High waist circumference; Hypoalphalipoproteinemia; Metabolic syndrome; NHANES
Authors: Alan S Go; Dariush Mozaffarian; Véronique L Roger; Emelia J Benjamin; Jarett D Berry; Michael J Blaha; Shifan Dai; Earl S Ford; Caroline S Fox; Sheila Franco; Heather J Fullerton; Cathleen Gillespie; Susan M Hailpern; John A Heit; Virginia J Howard; Mark D Huffman; Suzanne E Judd; Brett M Kissela; Steven J Kittner; Daniel T Lackland; Judith H Lichtman; Lynda D Lisabeth; Rachel H Mackey; David J Magid; Gregory M Marcus; Ariane Marelli; David B Matchar; Darren K McGuire; Emile R Mohler; Claudia S Moy; Michael E Mussolino; Robert W Neumar; Graham Nichol; Dilip K Pandey; Nina P Paynter; Matthew J Reeves; Paul D Sorlie; Joel Stein; Amytis Towfighi; Tanya N Turan; Salim S Virani; Nathan D Wong; Daniel Woo; Melanie B Turner Journal: Circulation Date: 2013-12-18 Impact factor: 29.690
Authors: Patricia M Guenther; Sharon I Kirkpatrick; Jill Reedy; Susan M Krebs-Smith; Dennis W Buckman; Kevin W Dodd; Kellie O Casavale; Raymond J Carroll Journal: J Nutr Date: 2014-01-22 Impact factor: 4.798
Authors: Peter Jarčuška; Martin Janičko; Peter Kružliak; Miroslav Novák; Eduard Veselíny; Ján Fedačko; Gabriela Senajová; Sylvia Dražilová; Andrea Madarasová-Gecková; Mária Mareková; Daniel Pella; Leonard Siegfried; Pavol Kristián; Eva Kolesárová Journal: Eur J Intern Med Date: 2014-01-17 Impact factor: 4.487
Authors: Mustapha Hajjou; Raquel Norel; Robert Carver; Patricia Marion; John Cullen; Leslie E Rogler; Charles E Rogler Journal: J Med Virol Date: 2005-09 Impact factor: 2.327
Authors: Ja Sung Choi; Ki Jun Han; Sangheun Lee; Song Wook Chun; Dae Jung Kim; Hyeon Chang Kim; Hee Man Kim Journal: J Epidemiol Date: 2014-10-04 Impact factor: 3.211