Zeynab Hematdar1, Negar Ghasemifard1, Gholamreza Phishdad2, Shiva Faghih1. 1. 1Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. 2. 2Department of Internal Medicine, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
Abstract
BACKGROUND AND AIMS: Several studies have documented that consumption of legumes including soybean is inversely associated with systemic inflammation and oxidative stress. This study was done to assess the effects of soy beans or non-soy legumes consumption on C-reactive protein (CRP) and malondialdehyde (MDA) among Patients with Type 2 Diabetes (T2D). METHODS: 75 persons with T2D participated in this randomized controlled clinical trial. Participants were randomized to one of the following 3 groups for 8 weeks: soy bean group (taking a cup of cooked soy beans three days a week), legumes group (taking a cup of cooked non-soy legumes three days a week) and control group (taking two servings of red meat three days a week). Anthropometric indices, dietary intakes, and serum MDA and CRP were measured at baseline and after intervention. RESULTS: A Significant decrease was observed in serum CRP of soy bean group (P = 0.01) which was significantly more than the controls (p = 0.001), while no significant changes of CRP was observed in legume group. Serum MDA changed significantly in none of the 3 groups. CONCLUSIONS: In conclusion, we found that substitution of red meat with soybean but not non- soy legumes may reduce inflammatory factors with no effects on oxidative stress in diabetic patients.
BACKGROUND AND AIMS: Several studies have documented that consumption of legumes including soybean is inversely associated with systemic inflammation and oxidative stress. This study was done to assess the effects of soy beans or non-soy legumes consumption on C-reactive protein (CRP) and malondialdehyde (MDA) among Patients with Type 2 Diabetes (T2D). METHODS: 75 persons with T2D participated in this randomized controlled clinical trial. Participants were randomized to one of the following 3 groups for 8 weeks: soy bean group (taking a cup of cooked soy beans three days a week), legumes group (taking a cup of cooked non-soy legumes three days a week) and control group (taking two servings of red meat three days a week). Anthropometric indices, dietary intakes, and serum MDA and CRP were measured at baseline and after intervention. RESULTS: A Significant decrease was observed in serum CRP of soy bean group (P = 0.01) which was significantly more than the controls (p = 0.001), while no significant changes of CRP was observed in legume group. Serum MDA changed significantly in none of the 3 groups. CONCLUSIONS: In conclusion, we found that substitution of red meat with soybean but not non- soy legumes may reduce inflammatory factors with no effects on oxidative stress in diabetic patients.
Authors: L Guariguata; D R Whiting; I Hambleton; J Beagley; U Linnenkamp; J E Shaw Journal: Diabetes Res Clin Pract Date: 2013-12-01 Impact factor: 5.602
Authors: Tobias Pischon; Susan E Hankinson; Gökhan S Hotamisligil; Nader Rifai; Walter C Willett; Eric B Rimm Journal: Circulation Date: 2003-06-23 Impact factor: 29.690
Authors: Casper H Jørgensen; Gunnar H Gislason; Ole Ahlehoff; Charlotte Andersson; Christian Torp-Pedersen; Peter R Hansen Journal: BMC Cardiovasc Disord Date: 2014-01-09 Impact factor: 2.298
Authors: Peter Celec; Július Hodosy; Roland Pálffy; Roman Gardlík; Lukáč Halčák; Daniela Ostatníková Journal: Molecules Date: 2013-05-07 Impact factor: 4.411
Authors: Jun Li; Dong Hoon Lee; Jie Hu; Fred K Tabung; Yanping Li; Shilpa N Bhupathiraju; Eric B Rimm; Kathryn M Rexrode; JoAnn E Manson; Walter C Willett; Edward L Giovannucci; Frank B Hu Journal: J Am Coll Cardiol Date: 2020-11-10 Impact factor: 24.094
Authors: Leila Khalili; Thoraya Mohamed Elhassan A-Elgadir; Ayaz Khurram Mallick; Hesham Ali El Enshasy; R Z Sayyed Journal: Front Nutr Date: 2022-03-29