Literature DB >> 3091841

The template properties of some oligodeoxynucleotides containing cytidine and guanosine.

T Haertle, L E Orgel.   

Abstract

The co-condensation of guanosine- and cytidine-5'-phospho-2-methylimidazolide on various oligodeoxynucleotides containing C and G has been studied. We find that GC7 is an effective template for the incorporation of C into products of the form GnC, whereas C7G does not act as a template for C incorporation. The template C3GC3GC3GC3 directs the synthesis of complementary products, but the yield of long oligomers is very small. Templates in which G residues are contiguous or separated by a single C residue are ineffective, while templates containing the sequence GCCG are very inefficient. The significance of these findings in the context of prebiotic chemistry is discussed.

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Year:  1986        PMID： 3091841     DOI： 10.1007/bf02099904

Source DB:  PubMed          Journal:  J Mol Evol        ISSN： 0022-2844            Impact factor:   2.395


  9 in total

1.  Template-directed synthesis on oligodeoxycytidylate and polydeoxycytidylate templates.

Authors:  C B Chen; T Inoue; L E Orgel
Journal:  J Mol Biol       Date:  1985-01-20       Impact factor: 5.469

2.  Non-enzymic template-directed synthesis on RNA random copolymers. Poly(C, G) templates.

Authors:  G F Joyce; L E Orgel
Journal:  J Mol Biol       Date:  1986-04-05       Impact factor: 5.469

3.  Template-directed synthesis on the pentanucleotide CpCpGpCpC.

Authors:  T Inoue; G F Joyce; K Grzeskowiak; L E Orgel; J M Brown; C B Reese
Journal:  J Mol Biol       Date:  1984-09-25       Impact factor: 5.469

4.  Oligomerization of (guanosine 5'-phosphor)-2-methylimidazolide on poly(C). An RNA polymerase model.

Authors:  T Inoue; L E Orgel
Journal:  J Mol Biol       Date:  1982-11-25       Impact factor: 5.469

5.  Nonenzymatic sequence-specific cleavage of single-stranded DNA.

Authors:  B C Chu; L E Orgel
Journal:  Proc Natl Acad Sci U S A       Date:  1985-02       Impact factor: 11.205

6.  Sequencing end-labeled DNA with base-specific chemical cleavages.

Authors:  A M Maxam; W Gilbert
Journal:  Methods Enzymol       Date:  1980       Impact factor: 1.600

7.  Template-directed synthesis on the oligonucleotide d(C7-G-C7).

Authors:  T Haertle; L E Orgel
Journal:  J Mol Biol       Date:  1986-03-05       Impact factor: 5.469

8.  Specific amino acid substitutions in bacterioopsin: Replacement of a restriction fragment in the structural gene by synthetic DNA fragments containing altered codons.

Authors:  K M Lo; S S Jones; N R Hackett; H G Khorana
Journal:  Proc Natl Acad Sci U S A       Date:  1984-04       Impact factor: 11.205

9.  Non-enzymatic template-directed synthesis on RNA random copolymers. Poly(C, U) templates.

Authors:  G F Joyce; T Inoue; L E Orgel
Journal:  J Mol Biol       Date:  1984-06-25       Impact factor: 5.469
  9 in total
  2 in total

1.  Information transfer from DNA to peptide nucleic acids by template-directed syntheses.

Authors:  J G Schmidt; L Christensen; P E Nielsen; L E Orgel
Journal:  Nucleic Acids Res       Date:  1997-12-01       Impact factor: 16.971

2.  Information transfer from peptide nucleic acids to RNA by template-directed syntheses.

Authors:  J G Schmidt; P E Nielsen; L E Orgel
Journal:  Nucleic Acids Res       Date:  1997-12-01       Impact factor: 16.971
  2 in total

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