Saman Qadri1, Carl D Langefeld1, Carol Milligan1, James B Caress1, Michael S Cartwright2. 1. From the Department of Neurosciences, Health Disparities in Neuroscience-related Disorders Program (S.Q., C.M.), and Departments of Biostatistics and Data Science (C.D.L.) and Neurology (J.B.C., M.S.C.), Wake Forest School of Medicine, Winston-Salem, NC. 2. From the Department of Neurosciences, Health Disparities in Neuroscience-related Disorders Program (S.Q., C.M.), and Departments of Biostatistics and Data Science (C.D.L.) and Neurology (J.B.C., M.S.C.), Wake Forest School of Medicine, Winston-Salem, NC. mcartwri@wakehealth.edu.
Abstract
OBJECTIVE: This study was conducted to determine whether longer lifespans in African Americans with amyotrophic lateral sclerosis (ALS), compared to white non-Hispanics, are secondary to higher rates of tracheostomy and invasive ventilation (TIV) in African Americans. METHODS: A retrospective case-control study was conducted with 49 African Americans with ALS matched by age, gender, and site of onset to 137 white persons with ALS. RESULTS: African Americans had longer survival than whites when the outcome was death (p = 0.016), but this was no longer significant when the outcome was death or TIV (p = 0.100). African Americans also had a lower rate of noninvasive ventilation use compared to whites (27 [55%] vs 96 [70%], p = 0.015) and a higher rate of TIV (8 [16%] vs 7 [5%], p = 0.016), but after controlling for baseline severity, only the noninvasive ventilation difference (p = 0.036), and not the TIV difference (p = 0.115), remained significant. CONCLUSION: African Americans with ALS live longer than white persons with ALS, and this may be secondary to higher rates of TIV use among African Americans.
OBJECTIVE: This study was conducted to determine whether longer lifespans in African Americans with amyotrophic lateral sclerosis (ALS), compared to white non-Hispanics, are secondary to higher rates of tracheostomy and invasive ventilation (TIV) in African Americans. METHODS: A retrospective case-control study was conducted with 49 African Americans with ALS matched by age, gender, and site of onset to 137 white persons with ALS. RESULTS: African Americans had longer survival than whites when the outcome was death (p = 0.016), but this was no longer significant when the outcome was death or TIV (p = 0.100). African Americans also had a lower rate of noninvasive ventilation use compared to whites (27 [55%] vs 96 [70%], p = 0.015) and a higher rate of TIV (8 [16%] vs 7 [5%], p = 0.016), but after controlling for baseline severity, only the noninvasive ventilation difference (p = 0.036), and not the TIV difference (p = 0.115), remained significant. CONCLUSION: African Americans with ALS live longer than white persons with ALS, and this may be secondary to higher rates of TIV use among African Americans.
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