Literature DB >> 30918064

Anti-parasitic drug discovery takes a giant leap forward.

Joseph T Nickels1.   

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Year:  2019        PMID： 30918064      PMCID： PMC6495171          DOI： 10.1194/jlr.C094250

Source DB:  PubMed          Journal:  J Lipid Res        ISSN： 0022-2275            Impact factor:   5.922


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  8 in total

1.  Mechanistic analysis of a multiple product sterol methyltransferase implicated in ergosterol biosynthesis in Trypanosoma brucei.

Authors:  Wenxu Zhou; Galina I Lepesheva; Michael R Waterman; W David Nes
Journal:  J Biol Chem       Date:  2006-01-12       Impact factor: 5.157

Review 2.  The Development of Drugs against Acanthamoeba Infections.

Authors:  Ruqaiyyah Siddiqui; Yousuf Aqeel; Naveed Ahmed Khan
Journal:  Antimicrob Agents Chemother       Date:  2016-10-21       Impact factor: 5.191

3.  Discovery of an ergosterol-signaling factor that regulates Trypanosoma brucei growth.

Authors:  Brad A Haubrich; Ujjal K Singha; Matthew B Miller; Craigen R Nes; Hosanna Anyatonwu; Laurence Lecordier; Presheet Patkar; David J Leaver; Fernando Villalta; Benoit Vanhollebeke; Minu Chaudhuri; W David Nes
Journal:  J Lipid Res       Date:  2014-11-25       Impact factor: 5.922

4.  24-Methylenecyclopropane steroidal inhibitors: A Trojan horse in ergosterol biosynthesis that prevents growth of Trypanosoma brucei.

Authors:  Matthew B Miller; Presheet Patkar; Ujjal K Singha; Minu Chaudhuri; W David Nes
Journal:  Biochim Biophys Acta Mol Cell Biol Lipids       Date:  2016-12-06       Impact factor: 4.698

Review 5.  Amoebas from the genus Acanthamoeba and their pathogenic properties

Authors:  Karolina Kot; Natalia A. Łanocha-Arendarczyk; Danuta I. Kosik-Bogacka
Journal:  Ann Parasitol       Date:  2018

6.  Fluorinated Sterols Are Suicide Inhibitors of Ergosterol Biosynthesis and Growth in Trypanosoma brucei.

Authors:  David J Leaver; Presheet Patkar; Ujjal K Singha; Matthew B Miller; Brad A Haubrich; Minu Chaudhuri; W David Nes
Journal:  Chem Biol       Date:  2015-10-22

7.  Sterol methyltransferase a target for anti-amoeba therapy: towards transition state analog and suicide substrate drug design.

Authors:  Medhanie E Kidane; Boden H Vanderloop; Wenxu Zhou; Crista D Thomas; Emilio Ramos; Ujjal Singha; Minu Chaudhuri; W David Nes
Journal:  J Lipid Res       Date:  2017-10-17       Impact factor: 5.922

8.  Steroidal antibiotics are antimetabolites of Acanthamoeba steroidogenesis with phylogenetic implications.

Authors:  Wenxu Zhou; Emilio Ramos; Xunlu Zhu; Paxtyn M Fisher; Medhanie E Kidane; Boden H Vanderloop; Crista D Thomas; Juqiang Yan; Ujjal Singha; Minu Chaudhuri; Michael T Nagel; W David Nes
Journal:  J Lipid Res       Date:  2019-02-01       Impact factor: 5.922
  8 in total

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