| Literature DB >> 3091786 |
M J Adam, T J Ruth, J R Grierson, B Abeysekera, B D Pate.
Abstract
The synthesis of L-[18F]6-fluorodopa (2.4-10.6 mCi) was done by passing gaseous [18F]acetyl hypofluorite through a solution of L-methyl-N- acetyl-[beta-(3-methoxy-4-acetoxyphenyl)]alaninate in acetic acid at room temperature followed by the hydrolysis of the intermediate products with concentrated hydriodic acid. The desired fluorodopa isomer was isolated in 8% EOB radiochemical yield by high performance liquid chromatography in an overall synthesis time of 100 min.Entities:
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Year: 1986 PMID： 3091786
Source DB: PubMed Journal: J Nucl Med ISSN： 0161-5505 Impact factor: 10.057