| Literature DB >> 30914332 |
Tianpeng Yin1, Yan Shu2, Hao Zhou2, Le Cai3, Zhongtao Ding4.
Abstract
Two novel 8,15-seco C19-diterpenoid alkaloids, nagarines A (1) and B (2), were isolated from the roots of Aconitum nagarum Stapf (Ranunculaceae), a folk herbal medicine used to treat rheumatism and arthritis in Southwestern China, Northern Burma and Northeastern India. They are the first C19-diterpenoid alkaloids possessing unprecedented opened D ring formed by the cleavage of the bond between C-8 and C-15. Compounds 1 and 2 showed certain inhibition activities of interleukin-6 in LPS-activated RAW 264.7 cells with IC50 values of 72.63 ± 0.39 μM and 52.98 ± 0.50 μM, respectively.Entities:
Keywords: Aconitum nagarum Stapf; Diterpenoid alkaloids; Interleukin-6; Ranunculaceae
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Year: 2019 PMID： 30914332 DOI： 10.1016/j.fitote.2019.03.021
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882