Literature DB >> 30914298

Nanoemulsions in CNS drug delivery: recent developments, impacts and challenges.

Zahra Karami1, Mohammad Reza Saghatchi Zanjani1, Mehrdad Hamidi2.   

Abstract

Despite enormous efforts, treatment of CNS diseases remains challenging. One of the main issues causing this situation is limited CNS access for the majority of drugs used as part of the therapeutic regimens against life-threatening CNS diseases. Regarding the inarguable position of the nanocarrier systems in neuropharmacokinetic enhancement of the CNS drugs, this review discusses the latest findings on nanoemulsions (NEs) as one of the most promising candidates of this type, to overcome the challenges of CNS drug delivery. Future development of NE-based CNS drug delivery needs to consider so many aspects not only from a physicochemical point of view but also related to the biointerface of these very small droplets before achieving clinical value.
Copyright © 2019 Elsevier Ltd. All rights reserved.

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Year:  2019        PMID： 30914298     DOI： 10.1016/j.drudis.2019.03.021

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  7 in total

1.  Development and Characterization of A New Dimethicone Nanoemulsion and its Application for Electronic Gastroscopy Examination.

Authors:  Suo-Min Feng; Cang-Bao Xu; Ying Zhao; Qing Xu; Hui-Min Li; Yu-Xiu Huang; Huan-Huan Liu
Journal:  Int J Nanomedicine       Date:  2020-07-29

Review 2.  Improving Drug Delivery for Alzheimer's Disease Through Nose-to-Brain Delivery Using Nanoemulsions, Nanostructured Lipid Carriers (NLC) and in situ Hydrogels.

Authors:  Sara Cunha; Ben Forbes; José Manuel Sousa Lobo; Ana Catarina Silva
Journal:  Int J Nanomedicine       Date:  2021-06-29

Review 3.  Nano-based drug delivery system: a smart alternative towards eradication of viral sanctuaries in management of NeuroAIDS.

Authors:  Nidhi Aggarwal; Bushra Nabi; Sumit Aggarwal; Sanjula Baboota; Javed Ali
Journal:  Drug Deliv Transl Res       Date:  2021-01-23       Impact factor: 4.617

4.  Development and Optimization of Nanoemulsion from Ethanolic Extract of Centella asiatica (NanoSECA) Using D-Optimal Mixture Design to Improve Blood-Brain Barrier Permeability.

Authors:  Nor Atiqah Jusril; Syahrul Imran Abu Bakar; Khalilah Abdul Khalil; Wan Mazlina Md Saad; Ng Kwok Wen; Mohd Ilham Adenan
Journal:  Evid Based Complement Alternat Med       Date:  2022-03-07       Impact factor: 2.629

Review 5.  Microemulsions and Nanoemulsions in Skin Drug Delivery.

Authors:  Eliana B Souto; Amanda Cano; Carlos Martins-Gomes; Tiago E Coutinho; Aleksandra Zielińska; Amélia M Silva
Journal:  Bioengineering (Basel)       Date:  2022-04-05

6.  Fingolimod Nanoemulsions at Different Particle Sizes Define the Fate of Spinal Cord Injury Recovery.

Authors:  Delaram Poormoghadam; Bita Rasoulian Shiadeh; Fereshte Azedi; Hani Tavakol; Seyed Mahdi Rezayat; Shima Tavakol
Journal:  Biomed Res Int       Date:  2022-08-16       Impact factor: 3.246

Review 7.  Microbial acetylcholinesterase inhibitors for Alzheimer's therapy: recent trends on extraction, detection, irradiation-assisted production improvement and nano-structured drug delivery.

Authors:  Amira G Zaki; El-Sayed R El-Sayed; M Abd Elkodous; Gharieb S El-Sayyad
Journal:  Appl Microbiol Biotechnol       Date:  2020-04-13       Impact factor: 5.560
  7 in total

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