Jose Curbelo1, Olga Rajas2, Belén Arnalich3, José María Galván-Román1, Sergio Luquero-Bueno4, Mara Ortega-Gómez4, Angel Lancho3, Emilia Roy1, Ana Sánchez Azofra2, Gloria Mateo Jiménez3, Manuel Gómez5, Fernando Moldenhauer1, Javier Aspa6. 1. Servicio de Medicina Interna, Hospital Universitario de La Princesa, Madrid, España. 2. Servicio de Neumología, Hospital Universitario de La Princesa, Madrid, España. 3. Servicio de Neumología, Hospital del Henares, Coslada, Madrid, España. 4. Biobanco del Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria del Hospital Universitario de la Princesa (IIS-IP), Madrid, España. 5. Unidad de Metodología, Instituto de Investigación Sanitaria del Hospital Universitario de la Princesa (IIS-IP), Madrid, España. 6. Servicio de Neumología, Hospital Universitario de La Princesa, Madrid, España. Electronic address: jaspa@separ.es.
Abstract
INTRODUCTION: Community-acquired pneumonia (CAP) is a common serious infection. This study aimed to evaluate the prognostic utility of neutrophil count percentage (NCP) and neutrophil-lymphocyte ratio (NLR) in patients with CAP. METHODS: Retrospective study of hospitalized patients with CAP. Patients had a blood test at admission and 3-5 days after hospitalization (early-stage test). The main outcome variables were 30-day and 90-day mortality. RESULTS: Two hundred and 9patients were included. Patients who survived had significant reductions in both NCP and NLR between admission and the day 3-5 blood tests (from 85.8% to 65.4% for NCP and from 10.1 to 3.2 for NLR). Twenty-five patients died in the first 90 days. Patients who died had lower, non-significant reductions in NCP (from 84.8% to 74%) and NLR (from 9.9 to 6.9) and significantly higher early-stage NCP and NLR than those who survived. NCP values higher than 85% and NLR values higher than 10 in the early-stage blood test were associated with a higher risk of mortality, even after multivariate adjustment (HR for NCP: 12; HR for NLR: 6.5). CONCLUSION: NCP and NLR are simple, low-cost parameters with prognostic utility, especially when measured 3-5 days after CAP diagnosis. High NLR and/or NCP levels are associated with a greater risk of mortality at 90 days.
INTRODUCTION: Community-acquired pneumonia (CAP) is a common serious infection. This study aimed to evaluate the prognostic utility of neutrophil count percentage (NCP) and neutrophil-lymphocyte ratio (NLR) in patients with CAP. METHODS: Retrospective study of hospitalized patients with CAP. Patients had a blood test at admission and 3-5 days after hospitalization (early-stage test). The main outcome variables were 30-day and 90-day mortality. RESULTS: Two hundred and 9patients were included. Patients who survived had significant reductions in both NCP and NLR between admission and the day 3-5 blood tests (from 85.8% to 65.4% for NCP and from 10.1 to 3.2 for NLR). Twenty-five patients died in the first 90 days. Patients who died had lower, non-significant reductions in NCP (from 84.8% to 74%) and NLR (from 9.9 to 6.9) and significantly higher early-stage NCP and NLR than those who survived. NCP values higher than 85% and NLR values higher than 10 in the early-stage blood test were associated with a higher risk of mortality, even after multivariate adjustment (HR for NCP: 12; HR for NLR: 6.5). CONCLUSION: NCP and NLR are simple, low-cost parameters with prognostic utility, especially when measured 3-5 days after CAP diagnosis. High NLR and/or NCP levels are associated with a greater risk of mortality at 90 days.
Authors: José María Galván-Román; Ángel Lancho-Sánchez; Sergio Luquero-Bueno; Lorena Vega-Piris; Jose Curbelo; Marcos Manzaneque-Pradales; Manuel Gómez; Hortensia de la Fuente; Mara Ortega-Gómez; Javier Aspa Journal: PLoS One Date: 2020-10-23 Impact factor: 3.240
Authors: Mai M Aly; Taghreed S Meshref; Marwa A Abdelhameid; Shimaa A Ahmed; Asmaa S Shaltout; Alaa Eldin Abdel-Moniem; Dina A Hamad Journal: J Blood Med Date: 2021-06-29