Literature DB >> 3091259

Local function of the Notch gene for embryonic ectodermal pathway choice in Drosophila.

P E Hoppe, R J Greenspan.   

Abstract

Mutations at the Notch locus affect the fate of cells in the neurogenic region of the Drosophila embryo so that epidermal precursors become neuroblasts. We have analyzed the cellular requirements for wild-type Notch gene function by means of genetic mosaics, using a cuticle marker to distinguish hypodermal cell genotype. Cells that were genotypically Notch never gave rise to hypoderm within the neurogenic region of mosaic embryos. Mosaic dividing lines within the neurogenic region juxtapose N+ hypoderm with regions of neural hypertrophy. This autonomous action of Notch in hypodermal cells is consistent with a local function of the protein during neurogenesis. Comparison of clone distribution in Notch mosaics and controls suggests that islands of wild-type hypodermal cells fail to differentiate cuticle.

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Year:  1986        PMID： 3091259     DOI： 10.1016/0092-8674(86)90353-3

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  26 in total

1.  Molecular basis of loss-of-function mutations in the glp-1 gene of Caenorhabditis elegans.

Authors:  V Kodoyianni; E M Maine; J Kimble
Journal:  Mol Biol Cell       Date:  1992-11       Impact factor: 4.138

Review 2.  Notch and the awesome power of genetics.

Authors:  Iva Greenwald
Journal:  Genetics       Date:  2012-07       Impact factor: 4.562

3.  Cell-autonomous role of Notch, an epidermal growth factor homologue, in sensory organ differentiation in Drosophila.

Authors:  J F de Celis; M Marí-Beffa; A García-Bellido
Journal:  Proc Natl Acad Sci U S A       Date:  1991-01-15       Impact factor: 11.205

4.  Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos.

Authors:  S Kidd; T Lieber; M W Young
Journal:  Genes Dev       Date:  1998-12-01       Impact factor: 11.361

5.  A cell marker system and mosaic patterns during early embryonic development in Drosophila melanogaster.

Authors:  S B Zusman; E Wieschaus
Journal:  Genetics       Date:  1987-04       Impact factor: 4.562

6.  Cell autonomy of expression of neurogenic genes of Drosophila melanogaster.

Authors:  G M Technau; J A Campos-Ortega
Journal:  Proc Natl Acad Sci U S A       Date:  1987-07       Impact factor: 11.205

7.  Regulatory signals and signal molecules in early neurogenesis of Drosophila melanogaster.

Authors:  José A Campos-Ortega; Marc Haenlin
Journal:  Rouxs Arch Dev Biol       Date:  1992-02

Review 8.  Initial neurogenesis in Drosophila.

Authors:  Volker Hartenstein; Andreas Wodarz
Journal:  Wiley Interdiscip Rev Dev Biol       Date:  2013-02-11       Impact factor: 5.814

Review 9.  The pathogenic role of Notch activation in podocytes.

Authors:  Thiruvur Niranjan; Mariana Murea; Katalin Susztak
Journal:  Nephron Exp Nephrol       Date:  2009-03-17

10.  The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis.

Authors:  Luisana Astudillo; Thiago G Da Silva; Zhiqiang Wang; Xiaoqing Han; Ke Jin; Jeffrey VanWye; Xiaoxia Zhu; Kelly Weaver; Taiji Oashi; Pedro E M Lopes; Darren Orton; Leif R Neitzel; Ethan Lee; Ralf Landgraf; David J Robbins; Alexander D MacKerell; Anthony J Capobianco
Journal:  Cancer Res       Date:  2016-04-13       Impact factor: 12.701
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