Aim: We used Adelphi Real World Disease-Specific Programme data to characterize adults with newly diagnosed or relapsed/refractory de novo acute myeloid leukemia (AML). Materials & methods: Community-practice hematologists/oncologists completed patient record forms for their regular AML patients. Patients were invited to complete patient self-completion forms including 3-Level EuroQol 5-Dimensions (EQ-5D-3L) and Functional Assessment of Cancer Therapy-Leukemia (FACT-Leu) questionnaires. Results: Physicians provided patient record forms for 389 patients (339 newly diagnosed, 50 relapsed/refractory); 68 patients completed patient self-completion forms. Mean EQ-5D visual-analog scale and index and FACT-General scores were significantly lower than US population norms (p < 0.0001); health-related quality of life (HRQoL) scores were generally lower than 11 other cancers. Conclusion: HRQoL impairment is grave in AML. Efforts are needed to improve HRQoL in affected patients.
Aim: We used Adelphi Real World Disease-Specific Programme data to characterize adults with newly diagnosed or relapsed/refractory de novo acute myeloid leukemia (AML). Materials & methods: Community-practice hematologists/oncologists completed patient record forms for their regular AMLpatients. Patients were invited to complete patient self-completion forms including 3-Level EuroQol 5-Dimensions (EQ-5D-3L) and Functional Assessment of Cancer Therapy-Leukemia (FACT-Leu) questionnaires. Results: Physicians provided patient record forms for 389 patients (339 newly diagnosed, 50 relapsed/refractory); 68 patients completed patient self-completion forms. Mean EQ-5D visual-analog scale and index and FACT-General scores were significantly lower than US population norms (p < 0.0001); health-related quality of life (HRQoL) scores were generally lower than 11 other cancers. Conclusion:HRQoL impairment is grave in AML. Efforts are needed to improve HRQoL in affected patients.
Entities:
Keywords:
acute myeloid leukemia; chemotherapy; clinical practice; community setting; quality of life; real-world
Authors: Keith W Pratz; Panayiotis Panayiotidis; Christian Recher; Xudong Wei; Brian A Jonas; Pau Montesinos; Vladimir Ivanov; Andre C Schuh; Courtney D DiNardo; Jan Novak; Vlatko Pejsa; Don Stevens; Su-Peng Yeh; Inho Kim; Mehmet Turgut; Nicola Fracchiolla; Kazuhito Yamamoto; Yishai Ofran; Andrew H Wei; Cat N Bui; Katy Benjamin; Rajesh Kamalakar; Jalaja Potluri; Wellington Mendes; Jacob Devine; Walter Fiedler Journal: Blood Cancer J Date: 2022-04-20 Impact factor: 9.812