| Literature DB >> 3091059 |
S Silberman, J Fareed, J Walenga.
Abstract
In vitro clotting activity of rats injected with different preparations of prothrombin concentrates was measured. Animals rendered deficient in vitamin K-dependent coagulation factors by early coumadin (warfarin) pretreatment, followed by injections of concentrate preparations were also evaluated. Findings indicate a dose-related response in abnormal coagulation changes demonstrable with each preparation and lack of protection of intravascular coagulation by coumadin anticoagulation. Furthermore, a role for in vivo factor VII activation of haemostasis following concentrate administration could not be elicited.Entities:
Mesh：
Substances：
Year: 1986 PMID： 3091059 PMCID： PMC2013040
Source DB: PubMed Journal: Br J Exp Pathol ISSN： 0007-1021